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Why RNA and DNA Have Different Structures

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 173)

Abstract

In the early years of molecular biology—over 50 years ago—we were faced with many unknowns. A significant one at the time was the relationship between DNA and RNA, both in terms of structure and function. Function is often a reflection of structure. Here I outline some of the early research in this area, especially for RNA structure, which was completely unknown when we started.

Keywords

RNA DNA Double helix X-ray structure 

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References

  1. Anonymous (1973) News and views. Nature 243:114Google Scholar
  2. Arnott S, Wilkins MHF, Hamilton LD, Langridge R (1965) Fourier synthesis studies of lithium DNA. III. Hoogsteen models. J Mol Biol 11:391–402PubMedGoogle Scholar
  3. Day RO, Seeman NC, Rosenberg JM, Rich A (1973) A crystalline fragment of the double helix: the structure of the dinucleoside phosphate guanylyl-3′, 5″-cytidine. Proc Natl Acad Sci USA 70:849–853PubMedGoogle Scholar
  4. Egli M, Usman N, Zhang S, Rich A (1992) Crystal structure of an Okazaki fragment at 2-Å resolution. Proc Natl Acad Sci USA 89:534–538PubMedGoogle Scholar
  5. Felsenfeld G, Davies DR, Rich A (1957) Formation of a three-stranded polynucleotide molecule. J Am Chem Soc 79:2023–2024CrossRefGoogle Scholar
  6. Franklin RE, Gosling RG (1953) Molecular configuration in sodium thymonucleate. Nature 171:740–741PubMedGoogle Scholar
  7. Furth JJ, Hurwitz J, Goldmann M (1961) The directing role of DNA in RNA synthesis. Biochem Biophys Res Commun 4:362–367PubMedGoogle Scholar
  8. Hoogsteen K (1959) The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine. Acta Crystallogr 12:822–823CrossRefGoogle Scholar
  9. Kim S-H, Quigley G, Suddath FL, Rich A (1971) High resolution X-ray diffraction patterns of tRNA crystals showing helical regions of the molecule. Proc Natl Acad Sci USA 68:841–845PubMedGoogle Scholar
  10. Kim S-H, Quigley GJ, Suddath FL, McPherson A, Sneden D, Kim JJ, Weinzierl J, Rich A (1973) Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain. Science 179:285–288PubMedGoogle Scholar
  11. Kim SH, Suddath FL, Quigley GJ, McPherson A, Sussman JL, Wang AH, Seeman NC, Rich A (1974) Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science 185:435–439PubMedGoogle Scholar
  12. Rich A (1960) A hybrid helix containing both deoxyribose and ribose polynucleotides and its relation to the transfer of information between the nucleic acids. Proc Natl Acad Sci USA 46:1044–1053Google Scholar
  13. Rich A (1962) On the problems of evolution and biochemical information transfer. In: Kasha M, Pullman B (eds) Horizons in biochemistry. Academic Press, New York, pp 103–126Google Scholar
  14. Rich A, Davies DR (1956) A new two-stranded helical structure: polyadenylic acid and polyuridylic acid. J Am Chem Soc 78:3548CrossRefGoogle Scholar
  15. Rich A, Watson JD (1954) Some relations between DNA and RNA. Proc Natl Acad Sci USA 40:759–764Google Scholar
  16. Rich A, Wang AHJ, Quigley GJ (1980) Diversity of sugar pucker in the nucleic acids. In: Ananchenko SN (ed) Frontiers of bioorganic chemistry and molecular biology (International Union of Pure and Applied Chemistry). Pergamon Press, Oxford, pp 327–343Google Scholar
  17. Robertus JD, Ladner JE, Finch JT, Rhodes D, Brown RS, Clark BF, Klug A (1974) A structure of yeast phenylalanine tRNA at 3 Å resolution. Nature 250:546–551CrossRefPubMedGoogle Scholar
  18. Rosenberg JM, Seeman NC, Kim JJP, Suddath FL, Nicholas HB, Rich A (1973) Double helix at atomic resolution. Nature 243:150–154CrossRefPubMedGoogle Scholar
  19. Tener GM, Khorana HG, Markham R, Pol EH (1958) Studies on polynucleotides. II. The synthesis and characterization of linear and cyclic thymidine oligonucleotides. J Am Chem Soc 80:6223–6230Google Scholar
  20. Voet D, Rich A (1970) The crystal structures of purine, pyrimidines and their intermolecular complexes. Prog Nucleic Acid Res Mol Biol 10:183–265PubMedGoogle Scholar
  21. Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A (1982) Molecular structure of r(GCG)d(TATACGC): aDNA-RNA hybrid helix joined to double helical DNA. Nature 299:601–604CrossRefPubMedGoogle Scholar
  22. Watson JD, Crick FHC (1953) A structure for deoxyribose nucleic acid. Nature 171:737–738PubMedGoogle Scholar
  23. Wilkins MHF, Randall JT (1953) Molecular structure of deoxypentose nucleic acids. Nature 171:738–740PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • A. Rich
    • 1
  1. 1.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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