Forebrain ischemia and the blood-cerebrospinal fluid barrier

  • S. R. Ennis
  • R. F. Keep
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 96)

Summary

Although the effects of cerebral ischemia on the blood-brain barrier have been extensively studied, the effects on the blood-cerebrospinal fluid barrier (BCSFB) at the choroid plexuses have received much less attention. This paper reviews evidence on the effects of cerebral ischemia on the choroid plexus, particularly focusing on the degree of blood flow reduction required to damage the lateral ventricle choroid plexuses during transient forebrain ischemia, and whether disruption of the BCSFB might affect nearby tissues.

Studies have shown that 2 common models of forebrain ischemia (4-vessel and 2-vessel with hypotension) cause damage to the lateral ventricle choroid plexus via necrosis and apoptosis. We have found that bilateral common carotid artery occlusion with hypotension causes an 87% reduction in lateral ventricle choroid plexus blood flow during ischemia and an approximate tripling of the permeability of the BCSFB to inulin after 6 hours of reperfusion. Interestingly, evidence suggests that this disruption of the BCSFB rather than disruption to the blood-brain barrier is the major cause of enhanced inulin entry into the hippocampus. The hippocampus undergoes selective delayed neuronal loss in that model of forebrain ischemia and the BCSFB disruption may participate in or modulate that delayed injury.

Keywords

Carotid artery occlusion hypotension stroke choroid plexus 

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References

  1. 1.
    Dienel GA (1984) Regional accumulation of calcium in postischemic rat brain. J Neurochem 43: 913–925PubMedGoogle Scholar
  2. 2.
    Ennis SR, Keep RF (2005) The effects of cerebral ischemia on the rat choroid plexus. J Cereb Blood Flow Metab [in press]Google Scholar
  3. 3.
    Ferrand-Drake M, Wieloch T (1999) The time-course of DNA fragmentation in the choroid plexus and the CA1 region following transient global ischemia in the rat brain. The effect of intraischemic hypothermia. Neuroscience 93: 537–549PubMedCrossRefGoogle Scholar
  4. 4.
    Ikeda J, Mies G, Nowak TS, Joo F, Klatzo I (1992) Evidence for increased calcium influx across the choroid plexus following brief ischemia of gerbil brain. Neurosci Lett 142: 257–259PubMedCrossRefGoogle Scholar
  5. 5.
    Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG (2000) Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms. Cell Mol Neurobiol 20: 197–216PubMedCrossRefGoogle Scholar
  6. 6.
    Keep RF, Xiang J, Ennis SR (2005) The blood-CSF barrier and cerebral ischemia. In: Zheng W, Chodobski A (eds) The blood-cerebrospinal fluid barrier. Taylor & Francis, Boca Raton, pp 245–260Google Scholar
  7. 7.
    Kitagawa H, Setoguchi Y, Fukuchi Y, Mitsumoto Y, Koga N, Mori T, Abe K (1998) DNA fragmentation and HSP72 gene expression by adenovirus-mediated gene transfer in postischemic gerbil hippocampus and ventricle. Metab Brain Dis 13: 211–223PubMedCrossRefGoogle Scholar
  8. 8.
    Liebeskind DS, Hurst RW (2004) Infarction of the choroid plexus. AJNR Am J Neuroradiol 25: 289–290PubMedGoogle Scholar
  9. 9.
    Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • S. R. Ennis
    • 1
  • R. F. Keep
    • 1
    • 2
  1. 1.Department of NeurosurgeryUniversity of MichiganAnn ArborUSA
  2. 2.Department of PhysiologyUniversity of MichiganAnn ArborUSA

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