Macrophages and dendritic cells treatment of spinal cord injury: from the bench to the clinic

  • M. Schwartz
  • E. Yoles
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 93)

Summary

The failure of the spinal cord to recover after injury has been associated with the immune privilege mechanism that suppresses immune activity throughout the central nervous system. Primed macrophages and dendritic cells were shown to promote neurological recovery in preclinical models of spinal cord injury. A cell therapy consisting of autologous incubated macrophages is now being tested on spinal cord injury patients in clinical trials.

Keywords

Cell therapy immune privilege neuroprotection neurodegeneration neuroimmunology 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Schwartz
    • 1
  • E. Yoles
    • 2
  1. 1.Department NeurophysiologyWeizmann Institute of ScienceRehovotIsrael
  2. 2.Proneuron BiotechnologiesNess ZionaIsrael

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