Immunologie und Pathogenese

Allen RL, O’Callaghan CA, McMichael AJ, Bowness P (1999) Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. J Immunol 162:5045–5048PubMedGoogle Scholar

Ball J (1971) Enthesopathy of rheumatoid and ankylosing spondylitis. Ann Rheum Dis 30:213–223PubMedGoogle Scholar

Benjamin M, McGonagle D (2001) The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat 199:503–526CrossRefPubMedGoogle Scholar

Bollow M, Fischer T, Reisshauer H, Backhaus M, Sieper J, Hamm B, Braun J (2000) Quantitative analyses of sacroiliac biopsies in spondyloarth-ropathies: T cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancement detected by magnetic resonance imaging. Ann Rheum Dis 59:135–140CrossRefPubMedGoogle Scholar

Boyle LH, Goodall JC, Opat SS, Gaston JS (2001) The recognition of HLA-B27 by human CD4(+) T lymphocytes. J Immunol 167:2619–2624PubMedGoogle Scholar

Braun J, Bollow M, Eggens U, Konig H, Distler A, Sieper J (1994) Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients. Arthritis Rheum 37:1039–1045PubMedGoogle Scholar

Braun J, Bollow M, Neure L, Seipelt E, Seyrekbasan F, Herbst H, Eggens U, Distler A, Sieper J (1995) Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum 38:499–505PubMedGoogle Scholar

Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W, Gromnica-Ihle E, Kellner H, Krause A, Schneider M, Sorensen H, Zeidler H, Thriene W, Sieper J (2002) Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 359:1187–1193CrossRefPubMedGoogle Scholar

Braun J, Khan MA, Sieper J (2000) Enthesitis and ankylosis in spondyloarthropathy: what is the target of the immune response? Ann Rheum Dis 59:985–994CrossRefPubMedGoogle Scholar

Braun J, Tuszewski M, Ehlers S, Häberle HJ, Bollow M, Eggens U, Distler A, Sieper J (1997) Use of a nested PCR strategy simultaneously targeting DNA sequences of multiple bacterial species in inflammatory joint diseases. II. Examination of sacroiliac and knee joint biopsies of patients with spondyloarthropathies and other arthritides. J Rheumatol 24:1101–1105PubMedGoogle Scholar

Braun J, Yin Z, Spiller I, Siegert S, Rudwaleit M, Liu L, Radbruch A, Sieper J (1999) Low secretion of tumor necrosis factor alpha, but no other Th1 or Th2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis. Arthritis Rheum 42:2039–2044CrossRefPubMedGoogle Scholar

Brown MA, Kennedy LG, MacGregor AJ, Dark C, Duncan E, Shatford JL, Taylor A, Calin A, Wordsworth P (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40:1823–1828PubMedGoogle Scholar

Colbert RA (2000) HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum? Mol Med Today 6:224–230CrossRefPubMedGoogle Scholar

Ekman P, Saarinen M, He Q, Gripenberg-Lerche C, Gronberg A, Arvilommi H, Granfors K (2002) HLA-B27-transfected (Salmonella permissive) and HLA-A2-transfected (Salmonella nonpermissive) human monocytic U937 cells differ in their production of cytokines. Infect Immun 70:1609–1614CrossRefPubMedGoogle Scholar

Francois RJ, Gardner DL, Degrave EJ, Bywaters EG (2000) Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis. Arthritis Rheum 43:2011–2024CrossRefPubMedGoogle Scholar

Hermann E, Yu DT, Meyer zum Büschenfelde KH, Fleischer B (1993) HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 342:646–650CrossRefPubMedGoogle Scholar

Höhler T, Schaper T, Schneider PM, Meyer zum Büschenfelde KH, Märker-Hermann E (1998) Association of different tumor necrosis factor alpha promoter allele frequencies with ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 41:1489–1492.CrossRefPubMedGoogle Scholar

Khan MA (2000) HLA-B27 polymorphism and association with disease. J Rheumatol 27:1110–1114PubMedGoogle Scholar

Kuon W, Holzhutter HG, Appel H, Grolms M, Kollnberger S, Traeder A, Henklein P, Weiss E, Thiel A, Lauster R, Bowness P, Radbruch A, Kloetzel PM, Sieper J (2001) Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases. J Immunol 167:4738–4746PubMedGoogle Scholar

Laval SH, Timms A, Edvards S, Bradbury L, Brophy S, Rubin L, Siminovitch KA, Weeks D, Calin A, Wordsworth BP, Brown MA (2001) Whole genome screening in ankylosing spondylitis — evidence of non-MHC genetic susceptibility loci. Am J Hum Genet 68:918–926PubMedGoogle Scholar

Leirisalo-Repo M (1998) Prognosis, course of disease, and treatment of the spondyloarthropathies. Rheum Dis Clin North Am 24:737–751PubMedGoogle Scholar

Maksymowych WP (2000) Ankylosing spondylitis — at the interface of bone and cartilage. J Rheumatol 27:2295–2301PubMedGoogle Scholar

Märker-Hermann E, Meyer zum Büschenfelde KH, Wildner G (1997) HLA-B27-derived peptides as autoantigens for T lymphocytes in ankylosing spondylitis. Arthritis Rheum 40:2047–2054PubMedGoogle Scholar

May E, Märker-Hermann E, Wittig BM, Zeitz M, Meyer zum Büschenfelde KH, Duchmann R (2000) Identical T-cell expansions in the colon mucosa and the synovium of a patient with enterogenic spondyloarthropathy. Gastroenterology 119:1745–1755PubMedGoogle Scholar

McGonagle D, Marzo-Ortega H, O’Connor P, Gibbon W, Pease C, Reece R, Emery P (2002) The role of biomechanical factors and HLA-B27 in magnetic resonance imaging-determined bone changes in plantar fascia enthesopathy. Arthritis Rheum 46:489–493CrossRefPubMedGoogle Scholar

Mielants H, Veys EM, Cuvelier C, De Vos M, Goemaere S, De Clercq L, Schatteman L, Gyselbrecht L, Elewaut D (1995) The evolution of spondyloarthropathies in relation to gut histology. III. Relation between gut and joint. J Rheumatol 22:2279–2284PubMedGoogle Scholar

Poole AR (1998) The histopathology of ankylosing spondylitis: are there unifying hypotheses? Am J Med Sci 316:228–33PubMedGoogle Scholar

Purrmann J, Zeidler H, Bertrams J, Juli E, Cleveland S, Berges W, Gemsa R, Specker C, Reis HE (1988) HLA antigens in ankylosing spondylitis associated with Crohn’s disease. Increased frequency of the HLA phenotype B27,B44. J Rheumatol 15:1658–1661PubMedGoogle Scholar

Robinson WP, van der Linden SM, Khan MA, Rentsch HU, Cats A, Russell A, Thomson G (1989) HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum 32:1135–1142PubMedGoogle Scholar

Rudwaleit M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A, Sieper J, Braun J (2001) Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis 60:36–42PubMedGoogle Scholar

Sieper J, Braun J (1995) Pathogenesis of spondylarthropathies. Persistent bacterial antigen, autoimmunity, or both? Arthritis Rheum 38:1547–1554PubMedGoogle Scholar

Sieper J, Fendler C, Laitko S, Sörensen H, Gripenberg-Lerche C, Hiepe F, Alten R, Keitel W, Groh A, Uksila J, Eggens U, Granfors K, Braun J (1999) No benefit of long-term Ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis. Arthritis Rheum 42:1386–1396CrossRefPubMedGoogle Scholar

Suarez-Almazor ME, Russell AS (1990) Sacroiliitis in psoriasis: relationship to peripheral arthritis and HLA-B27. J Rheumatol 17:804–808PubMedGoogle Scholar

Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Balish E, Hammer RE (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 180:2359–2364CrossRefPubMedGoogle Scholar

Ugrinovic S, Mertz A, Wu P, Braun J, Sieper J (1997) A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis. J Immunol 159:5715–5723PubMedGoogle Scholar

Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U, Sieper J (1997) Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum 40:1788–1797PubMedGoogle Scholar

Zhang Y, Guerassimov A, Leroux JY, Cartman A, Webber C, Lalic R, de Miguel E, Rosenberg LC, Poole AR (1998) Arthritis induced by proteoglycan aggrecan G1 domain in BALB/c mice. Evidence for t cell involvement and the immunosuppressive influence of keratan sulfate on recognition of t and b cell epitopes. J Clin Invest 101:1678–1686PubMedGoogle Scholar

Zou JX, Yiping Z, Thiel A, Rudwaleit M, Shi SL, Radbruch A, Poole R, Braun J, Sieper J (2003) Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumaoid arthritis. Rheumatology 42:846–855CrossRefPubMedGoogle Scholar