In Vitro Models for Simulating Swallowing
This chapter gives an overview of the in vitro models that are currently used for studying swallowing. The focus is on the construction, geometry, and performance of mechanical models. Swallowing simulations and mathematical modeling are also considered. The in vitro models that are concerned with the oral, pharyngeal, and esophageal phases of swallowing linked to bolus properties are discussed. The pharyngeal phase is given special consideration, as it is involved in both food transport to the stomach and air transport to the lungs, and therefore constitutes the most critical phase of swallowing.
The Swedish Scientific Council Formas is gratefully acknowledged for financing Waqas M Qazi. We thank Eva Ekman, Johan Wiklund, and Olle Ekberg for their valuable inputs. Fredrik Holmberg is gratefully acknowledged for the mechanical and electronic construction work on the Gothenburg Throat model.
- Hayoun P, Engmann J, Mowlavi S, Le Reverend B, Burbidge A, Ramaioli M (2015) A model experiment to understand the oral phase of swallowing of Newtonian liquids. J Biomech. https://doi.org/10.1016/j.jbiomech.2015.09.022
- Kikuchi T, Kobayashi H, Michiwaki Y (2009) Development of a swallowing robot reproducing hyoid bone and epiglottis during swallowing. In: Seventeenth annual dysphagia research society meeting, New Orleans, Louisiana.Google Scholar
- Koga H, Usuda Y, Matsuno M, Ogura Y, Ishii H, Solis J, Takanishi A, Katsumata A Development of the Oral Rehabilitation Robot WAO-1. In: Biomedical robotics and biomechatronics, 2008. BioRob 2008. 2nd IEEE RAS & EMBS International Conference on, 19–22 October 2008. pp 556–561. doi:10.1109/BIOROB.2008.4762801Google Scholar
- Noh Y, Shimomura A, Segawa M, Ishii H, Solis J, Takanishi A, Hatake K (2009) Development of tension/compression detection sensor system designed to acquire quantitative force information while training the airway management task. In: Advanced intelligent mechatronics, 2009. AIM 2009. IEEE/ASME International Conference on, 14–17 July 2009. pp 1264–1269. doi: https://doi.org/10.1109/AIM.2009.5229798
- Noh Y, Segawa M, Sato K, Wang C, Ishii H, Solis J, Takanishi A, Katsumata A, Iida Y (2011) Development of a robot which can simulate swallowing of food boluses with various properties for the study of rehabilitation of swallowing disorders. Paper presented at the International Conference on Robotics and AutomationGoogle Scholar
- Nystrom M, Qazi WM, Bülow M, Ekberg O, Stading M (2015) Effects of rheological factors on perceived ease of swallowing. Appl Rheol 25(6):40–48Google Scholar
- Stading M, Qazi W (2017) An in vitro model of the pharynx for evaluation of bolus flow, submittedGoogle Scholar
- Steele C, Alsanei W, Ayanikalath S, Barbon CA, Chen J, Cichero JY, Coutts K, Dantas R, Duivestein J, Giosa L, Hanson B, Lam P, Lecko C, Leigh C, Nagy A, Namasivayam A, Nascimento W, Odendaal I, Smith C, Wang H (2015) The influence of food texture and liquid consistency modification on swallowing physiology and function: a systematic review. Dysphagia 30(1):2–26. doi: 10.1007/s00455-014-9578-x CrossRefPubMedGoogle Scholar
- Waqas MQ, Wiklund J, Altskär A, Ekberg O, Stading M (2017) Shear and extensional rheology of commercial thickeners used for dysphagia management. J Texture Stud. doi: 10.1111/jtxs.12264
- Wiklund J, Shahram I, Stading M (2007) Methodology for in-line rheology by ultrasound Doppler velocity profiling and pressure difference techniques. Chemical Engineering Science 62(16):4277–4293. doi: 10.1016/j.ces.2007.05.007
- Wiklund J, Stading M (2008) Application of in-line ultrasound Doppler-based UVP–PD rheometry method to concentrated model and industrial suspensions. Flow Meas Instrum 19(3–4):171–179. https://doi.org/10.1016/j.flowmeasinst.2007.11.002 CrossRefGoogle Scholar
- William G. Paterson (2006) Esophageal peristalsis. doi: https://doi.org/10.1038/gimo13