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Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor

  • Francesca Felicia Caputi
  • Patrizia RomualdiEmail author
  • Sanzio Candeletti
Part of the Handbook of Experimental Pharmacology book series


Over the years, the ability of N/OFQ-NOP receptor system in modulating several physiological functions, including the release of neurotransmitters, anxiety-like behavior responses, modulation of the reward circuitry, inflammatory signaling, nociception, and motor function, has been examined in several brain regions and at spinal level. This chapter collects information related to the genes encoding the ppN/OFQ and NOP receptor, their regulation, and relative transcriptional control mechanisms. Furthermore, genetic manipulations, polymorphisms, and epigenetic alterations associated with different pathological conditions are discussed. The evidence here collected indicates that the study of ppN/OFQ and NOP receptor gene expression may offer novel opportunities in the field of personalized therapies and highlights this system as a good “druggable target” for different pathological conditions.


DNA methylation Epigenetics Gene expression Histone marks N/OFQ NOP−/− NOP-eGFP NOP receptor Polymorphisms ppN/OFQ 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Francesca Felicia Caputi
    • 1
  • Patrizia Romualdi
    • 1
    Email author
  • Sanzio Candeletti
    • 1
  1. 1.Department of Pharmacy and BiotechnologyAlma Mater Studiorum – University of BolognaBolognaItaly

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