Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis

  • Stefanie F. MaurerEmail author
  • Sebastian Dieckmann
  • Karin Kleigrewe
  • Cécilia Colson
  • Ez-Zoubir Amri
  • Martin Klingenspor
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 251)


Fatty acids are essential contributors to adipocyte-based non-shivering thermogenesis by acting as activators of uncoupling protein 1 and serving as fuel for mitochondrial heat production. Novel evidence suggests a contribution to this thermogenic mechanism by their conversion to bioactive compounds. Mammalian cells produce a plethora of oxylipins and endocannabinoids, some of which have been identified to affect the abundance or thermogenic activity of brown and brite adipocytes. These effectors are produced locally or at distant sites and signal toward thermogenic adipocytes via a direct interaction with these cells or indirectly via secondary mechanisms. These interactions are evoked by the activation of receptor-mediated pathways. The endogenous production of these compounds is prone to modulation by the dietary intake of the respective precursor fatty acids. The effect of nutritional interventions on uncoupling protein 1-derived thermogenesis may thus at least in part be conferred by the production of a supportive oxylipin and endocannabinoid profile. The manipulation of this system in future studies will help to elucidate the physiological potential of these compounds as novel, endogenous regulators of non-shivering thermogenesis.


Brite adipocytes Brown adipocytes Endocannabinoids Oxylipins PUFAs Thermogenesis Ucp1 ω-3 ω-6 



This work was supported by French Agence Nationale de la Recherche and Deutsche Forschungsgemeinschaft (ANR/DFG-15-CE14-0033 “Nutribrite”). We thank Tobias Fromme for proofreading the manuscript.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Stefanie F. Maurer
    • 1
    • 2
    Email author
  • Sebastian Dieckmann
    • 1
    • 2
  • Karin Kleigrewe
    • 3
  • Cécilia Colson
    • 4
  • Ez-Zoubir Amri
    • 4
  • Martin Klingenspor
    • 1
    • 2
  1. 1.Molecular Nutritional Medicine, Else Kröner-Fresenius Center for Nutritional MedicineTechnical University of MunichFreisingGermany
  2. 2.ZIEL Institute for Food and Health, TUM School of Life SciencesTechnical University of MunichFreisingGermany
  3. 3.Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS)Technical University of MunichFreisingGermany
  4. 4.Université Côte d’Azur, CNRS, Inserm, iBVNiceFrance

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