Targeting DNA Repair

  • Giuseppe CuriglianoEmail author
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 249)


Genomic instability is a characteristic of most human cancers and plays critical roles in both cancer development and progression. There are various forms of genomic instability arising from many different pathways, such as DNA damage from endogenous and exogenous sources, centrosome amplification, telomere damage, and epigenetic modifications. DNA-repair pathways can enable tumor cells to survive DNA damage. The failure to respond to DNA damage is a characteristic associated with genomic instability. Understanding of genomic instability in cancer is still very limited, but the further understanding of the molecular mechanisms through which the DNA damage response (DDR) operates, in combination with the elucidation of the genetic interactions between DDR pathways and other cell pathways, will provide therapeutic opportunities for the personalized medicine of cancer.


Cancer DNA damage Instability Resistance 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Early Drug Development for Innovative Therapy DivisionEuropean Institute of OncologyMilanItaly

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