Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.
KeywordsActivation GATA HIF Mitochondria Mitochondrial ROS MMP MnSOD NF-κB Reactive oxygen species Signal transduction Superoxide
This work was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 22592093 to H.J.M.) and the Strategic Promotion Program for Basic Nuclear Research (to H.J.M.) of the Ministry of Education, Culture, Sports, Science and Technology of Japan, and the Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry (BRAIN) (to H.J.M.) by the Ministry of Agriculture, Forestry and Fisheries of Japan. M.J.D. gratefully acknowledges financial support from the Novo Nordisk Foundation (Laureate Research Grant NNF13OC0004294).
Conflict of Interest
No potential conflicts of interest were disclosed.
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