Role of the cAMP Pathway in Glucose and Lipid Metabolism

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 233)

Abstract

3′–5′-Cyclic adenosine monophosphate (cyclic AMP or cAMP) was first described in 1957 as an intracellular second messenger mediating the effects of glucagon and epinephrine on hepatic glycogenolysis (Berthet et al., J Biol Chem 224(1):463–475, 1957). Since this initial characterization, cAMP has been firmly established as a versatile molecular signal involved in both central and peripheral regulation of energy homeostasis and nutrient partitioning. Many of these effects appear to be mediated at the transcriptional level, in part through the activation of the transcription factor CREB and its coactivators. Here we review current understanding of the mechanisms by which the cAMP signaling pathway triggers metabolic programs in insulin-responsive tissues.

Keywords

CBP (CREB Binding Protein) CREB (cAMP Response Element Binding protein) CRTC (cAMP Regulated Transcriptional Coactivator) 

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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Salk InstituteLa JollaUSA

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