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Porcine Acellular Lung Matrix in Wound Healing and Hernia Repair

  • Vishwanath Chegireddy
  • Koby D. Caplan
  • Joseph S. Fernandez-Moure
Chapter
Part of the Recent Clinical Techniques, Results, and Research in Wounds book series

Abstract

The introduction of synthetic polypropylene mesh in hernia repair has improved the results of herniorrhaphy. To introduce mesh is to introduce foreign bodies that can impact the human body and may lead to inflammation, infection, fibrosis, calcification, seromas, or adhesions to vital organs such as the bowel. Bioprosthetic meshes, generated from source organs source such as the dermis or small intestine, have emerged as commercially available products for use in hernia repair. The authors discuss the ideal mesh, tissue engineering and hernia repair, bioprosthetic mesh and use in the contaminated field, and porcine acellular lung matrix (PALM) as a natural scaffold capable of cell attachment, while maintaining cell viability was investigated as a novel prosthetic for repair and has demonstrated enhanced incorporation and short-term mechanical stability in a chronic ventral incisional hernia model with bridging repair.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Vishwanath Chegireddy
    • 1
    • 2
  • Koby D. Caplan
    • 1
    • 2
  • Joseph S. Fernandez-Moure
    • 1
    • 2
  1. 1.Department of SurgeryHouston Methodist HospitalHoustonUSA
  2. 2.Department of Biomimetic and Regenerative Medicine, Surgical Advanced Technologies LabHouston Methodist Research InstituteHoustonUSA

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