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Tailoring Bulk and Surface Composition of Polylactides for Application in Engineering of Skeletal Tissues

  • Gloria Gallego Ferrer
  • Andrea Liedmann
  • Marcus S. Niepel
  • Zhen-Mei Liu
  • Thomas Groth
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 282)

Abstract

Synthetic biodegradable polylactides have been used extensively to fabricate scaffolds for engineering skeletal tissues such as bone and cartilage. This chapter summarizes the application of polylactides in tissue engineering and shows strategies for tailoring its bulk and surface composition for optimized degradation rates, mechanical properties, and bioactivities that cannot be achieved with pure polylactide polymers. Hence, block copolymers and the use of blending as a cost-effective strategy are described here. Furthermore, polymeric networks are shown that are advantageous in porogen-leaching manufacture of scaffolds, in preventing crystallization during degradation, and in allowing the incorporation of hydrophilic chains. In addition, mechanical reinforcement of the polymer is achieved when organic–inorganic composites of polylactides are formed. The last part of this chapter focusses on the modification of the surface to tailor the biocompatibility of polylactides only, without changing the bulk properties of the material. Surface modification by wet chemical processes and adsorption of biogenic multilayers of glycosaminoglycans is described that not only significantly improves biocompatibility but may also help to drive differentiation of stem cells into the desired lineage.

Keywords

Blending Bone Cartilage Composites Copolymer Crosslinking Polyelectrolyte multilayers Polylactides Polymeric networks Surface modification 

Notes

Acknowledgments

This work was supported by Marie Curie Industry-Academia Partnerships and Pathways (FP7-PEOPLE-2012-IAPP, with grant agreement PIAP-GA-2012-324386) and IOF-Marie Curie fellowship program (Protdel 331655) as well as the German Research Society (DFG) through Grant GR 1290/10-1 and the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R Project (including Feder funds).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Gloria Gallego Ferrer
    • 1
    • 2
  • Andrea Liedmann
    • 3
  • Marcus S. Niepel
    • 3
    • 4
  • Zhen-Mei Liu
    • 5
  • Thomas Groth
    • 3
    • 4
  1. 1.Centre for Biomaterials and Tissue Engineering (CBIT)Universitat Politècnica de ValènciaValenciaSpain
  2. 2.Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)ZaragozaSpain
  3. 3.Biomedical Materials Group, Institute of PharmacyMartin Luther University Halle-WittenbergHalle (Saale)Germany
  4. 4.Interdisciplinary Center of Materials ScienceMartin Luther University Halle-WittenbergHalle (Saale)Germany
  5. 5.Faculty of DentistryUniversity of TorontoTorontoCanada

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