Chapter

Bioactive Surfaces

Volume 240 of the series Advances in Polymer Science pp 103-134

Date:

Self-Assembled Monolayers as Dynamic Model Substrates for Cell Biology

  • Abigail PulsipherAffiliated withDepartment of Chemistry, Carolina Center for Genome Science, The University of North Carolina at Chapel Hill
  • , Muhammad N. YousafAffiliated withDepartment of Chemistry, Carolina Center for Genome Science, The University of North Carolina at Chapel Hill Email author 

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Abstract

In recent years, the surface chemistry community has actively pursued the design and generation of stimuli-responsive platforms or dynamic surfaces to control the interface between cells and a solid support. Surface properties can be manipulated through photoactivation, electrochemical potential, pH change, and the addition of a biochemical signal, with the aim of mimicking the extracellular matrix and inducing cellular behavior. This chapter describes recent advances in the development and utility of self-assembled monolayers (SAMs) as dynamic, model substrates for cell biology.

Keywords

Biological interface Cell migration Cellular adhesion Dynamic substrates Immobilization Self-assembled monolayers