Nano- and Microgels Through Addition Reactions of Functional Oligomers and Polymers

  • Krystyna Albrecht
  • Martin Moeller
  • Juergen GrollEmail author
Part of the Advances in Polymer Science book series (POLYMER, volume 234)


Nano- and Microgels are predominantly prepared using radical polymerization techniques. This chapter reviews alternative approaches to microgel preparation based on addition reactions of functional oligomers and polymers. This allows preparation of microgels under physiological conditions and in the presence of biologically active molecules without affecting their function. This method is therefore predominantly used to synthesize microgels for biomedical applications. Different crosslinking chemistries that have been used in this context are presented and discussed with regard to reaction conditions and stability of the reaction product. Microgels that have been prepared by these techniques are divided into two groups. Natural polymers used for the preparation of microgels are described first, followed by artificial prepolymers that are suitable for the preparation of microgels. The different preparation methods as well as the resulting microgels and their properties are presented and discussed.


Addition reactions Disulfide bridges Drug delivery Michael addition Microgel Prepolymers 



Bovine brain microvessel endothelial cell lines


Bovine serum albumin


N,N -Carbonyldiimidazole


Cholesterol-bearing PuL


Cholesterol-bearing PuL nanogels






N,N -Dicyclohexylcarbodiimide


Dynamic light scattering


Dimethyl sulfoxide


Dithiobis(succinimidyl propionate)


Dimethyl 3, 3 -dithiobispropionimidate






Divinyl sulfone


Extracellular matrix


1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride


Ethylenediaminetetraacetic dianhydride


5-Fluoroadenine arabinoside








Lower critical solution temperature






Poly(aspartic acid)


Poly(ethylene glycol)


Poly(ethylene glycol)-octavinylsulfone


Poly(ethylene imine)










Reversible addition-fragmentation chain transfer polymerization


Scanning electron microscopy


Scanning force microscopy


Sulfanyl thiocarbonyl sulfanyl


Transmission electron microscopy




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Copyright information

© Springer 2010

Authors and Affiliations

  • Krystyna Albrecht
  • Martin Moeller
    • 1
  • Juergen Groll
    • 1
    Email author
  1. 1.DWI e.V. and Institute of Technical and Macromolecular ChemistryRWTH Aachen UniversityAachenGermany

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