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Shape-Memory Polymers for Biomedical Applications

  • Christopher M. Yakacki
  • Ken Gall
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 226)

Abstract

Shape-memory polymers (SMPs) are a class of mechanically functional “smart” materials that have generated substantial interest for biomedical applications. SMPs offer the ability to promote minimally invasive surgery, provide structural support, exert stabilizing forces, elute therapeutic agents, and biodegrade. This review focuses on several areas of biomedicine including vascular, orthopedic, and neuronal applications with respect to the progress and potential for SMPs to improve the standard of treatment in these areas. Fundamental studies on proposed biomedical SMP systems are discussed with regards to biodegradability, tailorability, sterilization, and biocompatibility. Lastly, a proposed research and development pathway for SMP-based biomedical devices is proposed based on trends in the recent literature.

Keywords

Biocompatibility Biomedical applications Medical devices Shape-memory polymers 

Abbreviations

ACL

Anterior cruciate ligament

CHEM

Cold hibernated elastic memory

DES

Drug-eluting stent

\({E}_{\mathrm{r}}^{{\prime}}\)

Rubbery modulus

EtO

Ethylene oxide

FDA

Food and Drug Administration

LTP

Low temperature plasma

PCL

Poly(ε-caprolactone)

PLA

Polylactic acid

PLLA

Poly(L-lactide)

SMP

Shape-memory polymer

Tdeform

Temperature of deformation

Tg

Glass transition temperature

Tonset

Onset of the glass transition

Ttrans

Transition temperature

US

United States

Notes

Acknowledgments

The authors would like to thank Jack “Mac” Griffis MS for his expert consultation in vascular devices. The authors would also like to thank Kurt Jacobus Ph.D., Carl Frick Ph.D., Alicia M. Ortega, Sean Dixon, Jordan Rakes, and Jhordan Gil for their support and careful review of this work.

References

  1. 1.
    Frost, Sullivan A (2005) Overview of US Medical Device Market #A662-54Google Scholar
  2. 2.
    Ratner BD, Bryant SJ (2004) Annu Rev Biomed Eng 6:41Google Scholar
  3. 3.
    Langer R, Tirrell DA (2004) Nature 428:487Google Scholar
  4. 4.
    Shmulewitz A, Langer R, Patton J (2006) Nat Biotechnol 24:277Google Scholar
  5. 5.
    Behl M, Lendlein A (2007) Soft Matter 3:58Google Scholar
  6. 6.
    Jagur-Grodzinski J (2006) Polym Adv Technol 17:395Google Scholar
  7. 7.
    Karp JM, Langer R (2007) Curr Opin Biotechnol 18:454Google Scholar
  8. 8.
    Langer R (1998) Nature 392:5Google Scholar
  9. 9.
    Liu C, Qin H, Mather PT (2007) J Mater Chem 17:1543Google Scholar
  10. 10.
    Ratna D, Karger-Kocsis J (2008) J Mater Sci 43:254Google Scholar
  11. 11.
    Lendlein A, Kelch S (2002) Angew Chem Int Ed 41:2034Google Scholar
  12. 12.
    Behl M, Lendlein A (2007) Mater Today 10:20Google Scholar
  13. 13.
    Gall K, Yakacki CM, Liu Y, Shandas R, Willett N, Anseth KS (2005) J Biomed Mater Res A 73:339Google Scholar
  14. 14.
    Yakacki CM, Shandas R, Lanning C, Rech B, Eckstein A, Gall K (2007) Biomaterials 28:2255Google Scholar
  15. 15.
    Yakacki CM, Shandas R, Safranski D, Ortega AM, Sassaman K, Gall K (2008) Adv Funct Mater 18:2428Google Scholar
  16. 16.
    Sharp AA, Panchawagh HV, Ortega A, Artale R, Richardson-Burns S, Finch DS, Gall K, Mahajan RL, Restrepo D (2006) J Neural Eng 3:L23Google Scholar
  17. 17.
    Metcalfe A, Desfaits AC, Salazkin I, Yahia L, Sokolowski WM, Raymond J (2003) Biomaterials 24:491Google Scholar
  18. 18.
    Small WT, Buckley PR, Wilson TS, Loge JM, Maitland KD, Maitland DJ (2008) J Biomed Opt 13:024018Google Scholar
  19. 19.
    Maitland DJ, Metzger MF, Schumann D, Lee A, Wilson TS (2002) Lasers Surg Med 30:1Google Scholar
  20. 20.
    Small W, Wilson TS, Benett WJ, Loge JM, Maitland DJ (2005) Opt Expr 13:8204Google Scholar
  21. 21.
    Baer GM, Small WT, Wilson TS, Benett WJ, Matthews DL, Hartman J, Maitland DJ (2007) Biomed Eng Online 6:43Google Scholar
  22. 22.
    Maitland DJ, Small WT, Ortega JM, Buckley PR, Rodriguez J, Hartman J, Wilson TS (2007) J Biomed Opt 12:030504Google Scholar
  23. 23.
    Buckley PR, McKinley GH, Wilson TS, Small W, Benett WJ, Bearinger JP, McElfresh MW, Maitland DJ (2006) IEEE Trans Biomed Eng 53:2075Google Scholar
  24. 24.
    Mohr R, Kratz K, Weigel T, Lucka-Gabor M, Moneke M, Lendlein A (2006) Proc Natl Acad Sci U S A 103:3540Google Scholar
  25. 25.
    Hazelton CS, Arzberger SC, Lake MS, Munshi NA (2007) J Adv Mater 39:35Google Scholar
  26. 26.
    Weigel T, Mohr R, Lendlein A (2009) Smart Mater Struct 18:9Google Scholar
  27. 27.
    Yakacki CM, Satarkar NS, Gall K, Likos R, Hilt JZ (2009) J Appl Polym SciGoogle Scholar
  28. 28.
    El Feninat F, Laroche G, Fiset M, Mantovani D (2002) Adv Eng Mater 4:91Google Scholar
  29. 29.
    Sokolowski W, Metcalfe A, Hayashi S, Yahia L, Raymond J (2007) Biomed Mater 2:S23Google Scholar
  30. 30.
    Lendlein A, Kelch S (2005) Clin Hemorheol Microcirc 32:105Google Scholar
  31. 31.
    Lendlein A, Canisius J, Schulte J, Kratz K (2004) Proceedings of the International Conference on Shape Memory and Superelastic Technologies SMST-2003 563Google Scholar
  32. 32.
    Sigwart U, Puel J, Mirkovitch V, Joffre F, Kappenberger L (1987) N Engl J Med 316:701Google Scholar
  33. 33.
    O’Brien B, Carroll W (2009) Acta Biomaterialia 5(4):945–958Google Scholar
  34. 34.
    Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O’Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y (2009) Circulation 119:e21Google Scholar
  35. 35.
    Lemos PA, Serruys PW, Sousa JE (2003) Circulation 107:3003Google Scholar
  36. 36.
    Newsome LT, Kutcher MA, Royster RL (2008) Anesth Analg 107:552Google Scholar
  37. 37.
    Winslow RD, Sharma SK, Kim MC (2005) Mt Sinai J Med 72:81Google Scholar
  38. 38.
    Fattori R, Piva T (2003) Lancet 361:247Google Scholar
  39. 39.
    Wache HM, Tartakowska DJ, Hentrich A, Wagner MH (2003) J Mater Sci Mater Med 14:109Google Scholar
  40. 40.
    Baer G, Wilson T, Maitland D, Matthews D (2006) J Investig Med 54:S162Google Scholar
  41. 41.
    Tamai H, Igaki K, Kyo E, Kosuga K, Kawashima A, Matsui S, Komori H, Tsuji T, Motohara S, Uehata H (2000) Circulation 102:399Google Scholar
  42. 42.
    Kessel DO, Patel JV (2005) Clin Radiol 60:413Google Scholar
  43. 43.
    Gobin YP, Starkman S, Duckwiler GR, Grobelny T, Kidwell CS, Jahan R, Pile-Spellman J, Segal A, Vinuela F, Saver JL (2004) Stroke 35:2848Google Scholar
  44. 44.
    Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP (2005) Stroke 36:1432Google Scholar
  45. 45.
    Metzger MF, Wilson TS, Schumann D, Matthews DL, Maitland DJ (2002) Biomed Microdevices 4:89Google Scholar
  46. 46.
    Maitland DJ, Metzger MF, Schumann D, Lee A, Wilson TS (2002) Lasers Surg Med 30:1Google Scholar
  47. 47.
    Small W, Metzger MF, Wilson TS, Maitland DJ (2005) IEEE J Sel Top Quantum Electronics 11:892Google Scholar
  48. 48.
    Wilson TS, Small IVW, Benett WJ, Bearinger JP, Maitland DJ (2005) Smart medical and biomedical sensor technology III, vol 6007. SPIE, Boston, MA, p 60070RGoogle Scholar
  49. 49.
    Small WT, Wilson TS, Buckley PR, Benett WJ, Loge JM, Hartman J, Maitland DJ (2007) IEEE Trans Biomed Eng 54:1657Google Scholar
  50. 50.
    Hartman J, Small W, Wilson TS, Brock J, Buckley PR, Benett WJ, Loge JM, Maitland DJ (2007) AJNR Am J Neuroradiol 28:872Google Scholar
  51. 51.
    Rinkel GJE, Djibuti M, Algra A, van Gijn J (1998) Stroke 29:251Google Scholar
  52. 52.
    Koebbe CJ, Veznedaroglu E, Jabbour P, Rosenwasser RH (2006) Neurosurgery 59:S93Google Scholar
  53. 53.
    Kallmes DF, Fujiwara NH (2002) Am J Neuroradiol 23:1580Google Scholar
  54. 54.
    Ahuja AA, Hergenrother RW, Strother CM, Rappe AA, Cooper SL, Graves VB (1993) AJNR Am J Neuroradiol 14:794Google Scholar
  55. 55.
    Hampikian JM, Heaton BC, Tong FC, Zhang ZQ, Wong CP (2006) Elsevier Science Bv, p 1373Google Scholar
  56. 56.
    Ortega J, Maitland D, Wilson T, Tsai W, Savas O, Saloner D (2007) Ann Biomed Eng 35:1870Google Scholar
  57. 57.
    Maitland DJ, Small W, Ortega JM, Buckley PR, Rodriguez J, Hartman J, Wilson TS (2007) J Biomed Opt 12:3Google Scholar
  58. 58.
    Small W, Buckley PR, Wilson TS, Benett WJ, Hartman J, Saloner D, Maitland DJ (2007) IEEE Trans Biomed Eng 54:1157Google Scholar
  59. 59.
    The United States Renal Data System (2008) 2:81Google Scholar
  60. 60.
    Van Tricht I, De Wachter D, Tordoir J, Verdonck P (2005) Ann Biomed Eng 33:1142Google Scholar
  61. 61.
    Ortega JM, Small WT, Wilson TS, Benett WJ, Loge JM, Maitland DJ (2007) IEEE Trans Biomed Eng 54:1722Google Scholar
  62. 62.
    Millennium_Research_Group (2007) US Markets for Orthopedic Soft Tissue Solutions 2008. US20ST07Google Scholar
  63. 63.
    Brand J Jr, Weiler A, Caborn DNM, Brown CH Jr, Johnson DL (2000) Am J Sports Med 28:761Google Scholar
  64. 64.
    Weiler A, Peine R, Pashmineh-Azar A, Abel C, Sudkamp NP, Hoffmann RF (2002) Arthroscopy 18:113Google Scholar
  65. 65.
    Piltz S, Strunk P, Meyer L, Plitz W, Lob G (2004) Knee Surg Sports Traumatol Arthrosc 12:376Google Scholar
  66. 66.
    Gall K, Yakacki CM, Griffis JC (2008) Society for biomaterials: translational research symposium, Atlanta, GAGoogle Scholar
  67. 67.
    Eliades T (2007) Am J Orthod Dentofacial Orthop 131:253Google Scholar
  68. 68.
    Jung YC, Cho JW (2008) J Mater Sci Mater Med. DOI: 10.1007/s10856-008-3538-7Google Scholar
  69. 69.
    Losken HW, Tschakaloff A, Vonoepen R, Mooney MP, Moritz O, Michaeli W, Lalikos J, Losken A (1994) Ann Plast Surg 32:606Google Scholar
  70. 70.
    Patyk A, Wollschlager B, Merten HA (2003) Mund Kiefer Gesichtschir 7:151Google Scholar
  71. 71.
    Pietrzak WS, Eppley BL (2007) J Craniofac Surg 18:540Google Scholar
  72. 72.
    Penfield W (1950) Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr 185:670Google Scholar
  73. 73.
    Mountcastle VB, Steinmetz MA, Romo R (1990) J Neurosci 10:3032Google Scholar
  74. 74.
    Wessberg J, Stambaugh CR, Kralik JD, Beck PD, Laubach M, Chapin JK, Kim J, Biggs SJ, Srinivasan MA, Nicolelis MA (2000) Nature 408:361Google Scholar
  75. 75.
    Horwitz GD, Newsome WT (2001) J Neurophysiol 86:2527Google Scholar
  76. 76.
    Kralik JD, Dimitrov DF, Krupa DJ, Katz DB, Cohen D, Nicolelis MA (2001) Methods 25:121Google Scholar
  77. 77.
    Katz DB, Simon SA, Nicolelis MA (2002) J Neurosci 22:1850Google Scholar
  78. 78.
    Kay LM, Laurent G (1999) Nat Neurosci 2:1003Google Scholar
  79. 79.
    Laubach M, Wessberg J, Nicolelis MA (2000) Nature 405:567Google Scholar
  80. 80.
    Shuler MG, Krupa DJ, Nicolelis MA (2002) Cereb Cortex 12:86Google Scholar
  81. 81.
    Williams JC, Rennaker RL, Kipke DR (1999) Brain Res Brain Res Protoc 4:303Google Scholar
  82. 82.
    Lendlein A, Schmidt AM, Langer R (2001) Proc Natl Acad Sci U S A 98:842Google Scholar
  83. 83.
    Lendlein A, Langer R (2002) Science 296:1673Google Scholar
  84. 84.
    Min CC, Cui WJ, Bei JZ, Wang SG (2005) Polym Adv Technol 16:608Google Scholar
  85. 85.
    Wang W, Ping P, Chen X, Jing X (2006) Eur Polym J 42:1240Google Scholar
  86. 86.
    Lu XL, Cai W, Gao ZY, Tang WJ (2007) Polym Bull 58:381Google Scholar
  87. 87.
    Zheng X, Zhou S, Li X, Weng J (2006) Biomaterials 27:4288Google Scholar
  88. 88.
    Wang WS, Ping P, Chen XS, Jing XB (2006) Eur Polym J 42:1240Google Scholar
  89. 89.
    Zheng X, Zhou S, Yu X, Li X, Feng B, Qu S, Weng J (2008) J Biomed Mater Res B Appl Biomater 86:170Google Scholar
  90. 90.
    Liu C, Mather PT (2002) J Appl Med Polym 6:47Google Scholar
  91. 91.
    Yakacki CM, Willis S, Luders C, Gall K (2008) Adv Eng Mater 10:112Google Scholar
  92. 92.
    Safranski DL, Gall K (2008) Polymer 49:4446Google Scholar
  93. 93.
    Choi NY, Lendlein A (2007) Soft Matter 3:901Google Scholar
  94. 94.
    Kelch S, Steuer S, Schmidt AM, Lendlein A (2007) Biomacromolecules 8:1018Google Scholar
  95. 95.
    Hayashi S (1993) Int Prog Urethanes 6:90Google Scholar
  96. 96.
    Hayashi S, Kondo S, Giordano C (1994) Antec 94:1998Google Scholar
  97. 97.
    Baer G, Wilson TS, Matthews DL, Maitland DJ (2007) J Appl Polym Sci 103:3882Google Scholar
  98. 98.
    Lin JR, Chen LW (1998) J Appl Polym Sci 69:1575Google Scholar
  99. 99.
    Lin JR, Chen LW (1998) J Appl Polym Sci 69:1563Google Scholar
  100. 100.
    Ping P, Wang W, Chen X, Jing X (2007) J Polym Sci B Polym Phys 45:557Google Scholar
  101. 101.
    Ping P, Wang W, Chen X, Jing X (2005) Biomacromolecules 6:587Google Scholar
  102. 102.
    Alteheld A, Feng Y, Kelch S, Lendlein A (2005) Angew Chem Int Ed Engl 44:1188Google Scholar
  103. 103.
    Wilson TS, Bearinger JP, Herberg JL, Marion JE, Wright WJ, Evans CL, Maitland DJ (2007) J Appl Polym Sci 106:540Google Scholar
  104. 104.
    Nair PD (1995) J Biomater Appl 10:121Google Scholar
  105. 105.
    Athanasiou KA, Niederauer GG, Agrawal CM (1996) Biomaterials 17:93Google Scholar
  106. 106.
    Clough RL (2001) Nucl Instrum Methods Phys Res B 185:8Google Scholar
  107. 107.
    Rozema FR, Bos RRM, Boering G, Vanasten JAAM, Nijenhuis AJ, Pennings AJ (1991) J Appl Biomater 2:23Google Scholar
  108. 108.
    Kelsey JC (1961) J Clin Pathol 14:59Google Scholar
  109. 109.
    Lerouge S, Tabrizian M, Wertheimer MR, Marchand R, Yahia L (2002) Biomed Mater Eng 12:3Google Scholar
  110. 110.
    Ikarashi Y, Tsuchiya T, Nakamura A (1995) Biomaterials 16:177Google Scholar
  111. 111.
    Leonard D, Buchanan F, Farrar D (2006) Plast Rubber Compos 35:303Google Scholar
  112. 112.
    Loo SCJ, Ooi CP, Boey YCF (2005) Biomaterials 26:3809Google Scholar
  113. 113.
    Filipczak K, Wozniak M, Ulanski P, Olah L, Przybytniak G, Olkowski RM, Lewandowska-Szumiel M, Rosiak JM (2006) Macromol Biosci 6:261Google Scholar
  114. 114.
    Rickert D, Lendlein A, Schmidt AM, Kelch S, Roehlke W, Fuhrmann R, Franke RP (2003) J Biomed Mater Res B Appl Biomater 67:722Google Scholar
  115. 115.
    Cabanlit M, Maitland D, Wilson T, Simon S, Wun T, Gershwin ME, Van de Water J (2007) Macromol Biosci 7:48Google Scholar
  116. 116.
    Faré S, Valtulina V, Petrini P, Alessandrini E, Pietrocola G, Tanzi MC, Speziale P, Visai L (2005) J Biomed Mater Res A 73:1Google Scholar
  117. 117.
    Yakacki CM, Lyons MB, Rech B, Gall K, Shandas R (2008) Biomed Mater 3:015010Google Scholar
  118. 118.
    Huang WM, Yang B, An L, Li C, Chan YS (2005) Appl Phys Lett 86:114105Google Scholar
  119. 119.
    Yang B, Huang WM, Li C, Li L (2006) Polymer 47:1348Google Scholar
  120. 120.
    Tobushi H, Matsui R, Hayashi S, Shimada D (2004) Smart Mater Struct 13:881Google Scholar
  121. 121.
    Tobushi H, Hayashi S, Hoshio K, Miwa N (2006) Smart Mater Struct 15:1033Google Scholar
  122. 122.
    Tobushi H, Hayashi S, Hoshio K, Ejiri Y (2008) Sci Technol Adv Mater 9:7Google Scholar
  123. 123.
    Yang B, Huang WM, Li C, Lee CM, Li L (2004) Smart Mater Struct 13:191Google Scholar
  124. 124.
    Schmidt AM (2006) Macromol Rapid Commun 27:1168Google Scholar
  125. 125.
    Smith KE, Temenoff JS, Gall K (2009) J Appl Polym Sci 114:2711Google Scholar
  126. 126.
    Baer GM, Small W, Wilson TS, Benett WJ, Matthews DL, Hartman J, Maitland DJ (2007) Biomed Eng Online 6Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Research and DevelopmentMedShape SolutionsAtlantaUSA
  2. 2.School of Materials Science and EngineeringThe Georgia Institute of TechnologyAtlantaUSA
  3. 3.George Woodruff School of Mechanical EngineeringThe Georgia Institute of TechnologyAtlantaUSA

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