Electronic Excitations in Guanine Quadruplexes

  • Pascale Changenet-Barret
  • Ying Hua
  • Dimitra Markovitsi
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 356)


Guanine rich DNA strands, such as those encountered at the extremities of human chromosomes, have the ability to form four-stranded structures (G-quadruplexes) whose building blocks are guanine tetrads. G-quadruplex structures are intensively studied in respect of their biological role, as targets for anticancer therapy and, more recently, of their potential applications in the field of molecular electronics. Here we focus on their electronic excited states which are compared to those of non-interacting mono-nucleotides and those of single and double stranded structures. Particular emphasis is given to excited state relaxation processes studied by time-resolved fluorescence spectroscopy from femtosecond to nanosecond time scales. They include ultrafast energy transfer and trapping of ππ* excitations by charge transfer states. The effect of various structural parameters, such as the nature of the metal cations located in the central cavity of G-quadruplexes, the number of tetrads or the conformation of the constitutive single strands, are examined.


Charge transfer states DNA fluorescence Energy transfer Excitons Guanine quadruplexes Molecular electronics Multi-scale dynamics 



The French National Agency for Research (ANR-12-BS08-0001-01) is acknowledged for financial support.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Pascale Changenet-Barret
    • 1
  • Ying Hua
    • 1
  • Dimitra Markovitsi
    • 1
  1. 1.CNRS, IRAMIS, LIDYL, Laboratoire Francis Perrin, URA 2453Gif-sur-YvetteFrance

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