Solid-State NMR Spectroscopy of Proteins

Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 335)

Abstract

Solid-state NMR spectroscopy proved to be a versatile tool for characterization of structure and dynamics of complex biochemical systems. In particular, magic angle spinning (MAS) solid-state NMR came to maturity for application towards structural elucidation of biological macromolecules. Current challenges in applying solid-state NMR as well as progress achieved recently will be discussed in the following chapter focusing on conceptual aspects important for structural elucidation of proteins.

Keywords

Amyloid fibrils Biomolecular solid-state NMR spectroscopy Dynamic nuclear polarization Membrane proteins 

Abbreviations

APP

Amyloid precursor protein

ASR

Anabaena sensory rhodopsin

CE

Cross-effect

CRAMPS

Combined rotation and multiple pulse spectroscopy

CW

Continuous wave

DARR

Dipolar assisted rotational resonance

DNP

Dynamic nuclear polarization

EPR

Electron paramagnetic resonance

FSLG

Frequency-switched Lee-Goldburg

GPCR

G protein-coupled receptor

HORROR

Homonuclear rotary resonance

INEPT

Insensitive nuclei enhanced by polarization transfer

MAS

Magic angle spinning

PDSD

Proton-driven spin diffusion

PMLG

Phase-modulated Lee-Goldburg

PRE

Paramagnetic relaxation enhancement

REDOR

Rotational echo double resonance

SE

Solid effect

TEDOR

Transferred echo double resonance

TM

Transmembrane helix

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Henrik Müller
    • 1
    • 2
  • Manuel Etzkorn
    • 1
    • 2
  • Henrike Heise
    • 1
    • 2
  1. 1.Institute of Physical BiologyHeinrich-Heine-University of DüsseldorfDüsseldorfGermany
  2. 2.Institute of Complex Systems, Structural Biochemistry (ICS-6)Research Center JülichJülichGermany

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