Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds

Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 331)

Abstract

This review focuses on the recent applications of matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF-MS) technologies for analysis of small molecular compounds (SMCs) on qualitative and quantitative levels to provide valuable information for the relative chemical and biochemical researches. We summarized the approaches to minimize the interference in low m/z range and ion suppression effects by adding chemical reagents, sample cleaning and preparation, matrix selection and performing chromatographic separation before MALDI TOF-MS analysis. Meanwhile, we discussed the strategies to enhance the MALDI TOF-MS detection sensitivity and selectivity by derivatization to attach the “charge tags” to SMCs. In addition, the mass spectrometric imaging (MSI) methods for locating the target SMCs in bio-tissues by MALDI TOF-MS were reviewed. Furthermore, the applications of MALDI TOF-MS for monitoring enzyme reactions and the screening of their inhibitors were also presented. Finally, the chemical applications of MALDI TOF-MS on characterization of small molecular transition-metal complexes and monitoring the organic reactions, especially the polymerization reactions, were discussed.

Keywords

MALDI TOF-MS Mass spectrometry Small molecule Transition-metal organometallic compounds 

Abbreviations

AChE

Acetylcholinesterase

CAD

Collision-activated dissociation

CHCA

α-Cyano-4-hydroxycinnamic acid

CID

Collision-induced dissociation

CNTs

Oxidized carbon nanotubes

CT

Charge-transfer ionization

DCTB

2-[(2E)-3-4-(tert-butylphenyl)-2-methylprop-2-enylidene] malononitrile

DHB

2,5-Dihydroxybenzoic acid

DIOS

Desorption/ionization on silicon

ESI

Electrospray ionization

FTICR-MS

Fourier transform ion cyclotron resonance mass spectrometry

LC

Liquid chromatography

MALDI

Matrix assisted laser desorption ionization

MS

Mass spectrometry or mass spectrometer

MS/MS

Tandem mass spectrometry

MSI

Mass spectrometric imaging

NALDI

Nano-assisted laser desorption–ionization

NAPIQ

N-alkylpyridinium isotope quaternization

SALDI

Surface-assisted laser desorption/ionization

SMCs

Small molecular compounds

SRM

Selected ion reaction monitoring

TLC

Thin layer chromatography

TOF-MS

Time-of-flight mass spectrometer

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Shanghai Mass Spectrometry Center, Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghaiPeople’s Republic of China

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