Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds

  • Haoyang WangEmail author
  • Zhixiong Zhao
  • Yinlong Guo
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 331)


This review focuses on the recent applications of matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF-MS) technologies for analysis of small molecular compounds (SMCs) on qualitative and quantitative levels to provide valuable information for the relative chemical and biochemical researches. We summarized the approaches to minimize the interference in low m/z range and ion suppression effects by adding chemical reagents, sample cleaning and preparation, matrix selection and performing chromatographic separation before MALDI TOF-MS analysis. Meanwhile, we discussed the strategies to enhance the MALDI TOF-MS detection sensitivity and selectivity by derivatization to attach the “charge tags” to SMCs. In addition, the mass spectrometric imaging (MSI) methods for locating the target SMCs in bio-tissues by MALDI TOF-MS were reviewed. Furthermore, the applications of MALDI TOF-MS for monitoring enzyme reactions and the screening of their inhibitors were also presented. Finally, the chemical applications of MALDI TOF-MS on characterization of small molecular transition-metal complexes and monitoring the organic reactions, especially the polymerization reactions, were discussed.


MALDI TOF-MS Mass spectrometry Small molecule Transition-metal organometallic compounds 





Collision-activated dissociation


α-Cyano-4-hydroxycinnamic acid


Collision-induced dissociation


Oxidized carbon nanotubes


Charge-transfer ionization


2-[(2E)-3-4-(tert-butylphenyl)-2-methylprop-2-enylidene] malononitrile


2,5-Dihydroxybenzoic acid


Desorption/ionization on silicon


Electrospray ionization


Fourier transform ion cyclotron resonance mass spectrometry


Liquid chromatography


Matrix assisted laser desorption ionization


Mass spectrometry or mass spectrometer


Tandem mass spectrometry


Mass spectrometric imaging


Nano-assisted laser desorption–ionization


N-alkylpyridinium isotope quaternization


Surface-assisted laser desorption/ionization


Small molecular compounds


Selected ion reaction monitoring


Thin layer chromatography


Time-of-flight mass spectrometer



The authors express great thanks to Prof. Dr. Deryn E. Fogg in University of Ottawa and Jürgen Schiller in Universität Leipzig for their generosity and for kindly providing their publications. The authors acknowledge financial support from NSFC (20902104, 21072215, and 21172250), Innovation Method Fund of China (2010IM030900), and CAS (YZ200938, YG2010056).


  1. 1.
    Karas M, Bachman D, Bahr U, Hillenkamp F (1987) Int J Mass Spectrom Ion Process 78:53–68CrossRefGoogle Scholar
  2. 2.
    Tanaka K, Waki H, Ido Y, Akita S, Yoshida Y, Yoshida T, Matsuo T (1988) Rapid Commun Mass Spectrom 2:151–153CrossRefGoogle Scholar
  3. 3.
    Castro JA, Köster C, Wilkins C, Cotter R (1992) Rapid Commun Mass Spectrom 6:239–241CrossRefGoogle Scholar
  4. 4.
    Karas M, Hillenkamp F (1988) Anal Chem 60:2299–2301CrossRefGoogle Scholar
  5. 5.
    Mustafa DAN, Burgers PC, Dekker LJ, Charif H, Titulaer MK, Sillevis Smitt PAE, Luider TM, Kros JM (2007) Mol Cell Proteomics 6:1147–1157CrossRefGoogle Scholar
  6. 6.
    Dekker LJ, Burgers PC, Gűzel C, Luider TM (2007) J Chromatogr B 847:62–64CrossRefGoogle Scholar
  7. 7.
    Franz AH, Molinski TF, Lebrilla CB (2001) J Am Soc Mass Spectrom 12:1254–1261CrossRefGoogle Scholar
  8. 8.
    Mizuno Y, Sasagawa T, Dohmae N, Takio K (1999) Anal Chem 71:4764–4771CrossRefGoogle Scholar
  9. 9.
    Dey M, Castoro JA, Wilkins CL (1995) Anal Chem 67:1575–1579CrossRefGoogle Scholar
  10. 10.
    Li QB, Li FX, Jia L, Li Y, Liu YC, Yu JY, Fang Q, Cao AM (2006) Biomacromolecules 7:2377–2387CrossRefGoogle Scholar
  11. 11.
    Senko MW, McLafferty FW (1994) Annu Rev Biophys Biomol Struct 23:763–785CrossRefGoogle Scholar
  12. 12.
    Cohen LH, Gusev AI (2002) Anal Bioanal Chem 373:571–586CrossRefGoogle Scholar
  13. 13.
    Hillenkamp F, Peter-Katalinić J (2007) MALDI MS – a practical guide to instrumentation, methods and application. Wiley-VCH, WeinheimGoogle Scholar
  14. 14.
    Fenn JB, Mann M, Meng CK, Wong SF, Whitehouse CM (1989) Science 246:64–71CrossRefGoogle Scholar
  15. 15.
    Hager JW (2004) Anal Bioanal Chem 378:845–850CrossRefGoogle Scholar
  16. 16.
    Yergey AL, Coorssen JR, Backlund PS, Blank PS, Humphrey GA, Zimmerberg J, Campbell JM, Vestal ML (2002) J Am Soc Mass Spectrom 13:784–791CrossRefGoogle Scholar
  17. 17.
    Hunnam V, Harvey DJ, Priestman DA, Bateman RH, Bordoli RS, Tyldesley R (2001) J Am Soc Mass Spectrom 12:1220–1225CrossRefGoogle Scholar
  18. 18.
    Suzuki Y, Suzuki M, Ito E, Goto-Inoue N, Miseki K, Lida J, Yamazaki Y, Yamada M, Suzuki A (2006) J Biochem 139:771–777CrossRefGoogle Scholar
  19. 19.
    Vestal ML, Campbell JM (2005) Methods Enzymol 402:79–108CrossRefGoogle Scholar
  20. 20.
    Gross JH (2004) Mass spectrometry: a textbook. Springer, BerlinGoogle Scholar
  21. 21.
    Ingendoh A, Karas M, Hillenkamp F, Giessmann U (1994) Int J Mass Spectrom Ion Process 131:345–354CrossRefGoogle Scholar
  22. 22.
    van Kampen JJA, Burgers PC, de Groot R, Gruters RA, Luider TM (2011) Mass Spectrom Rev 30:101–120CrossRefGoogle Scholar
  23. 23.
    Higashi T, Shimada K (2004) Anal Bioanal Chem 378:875–882CrossRefGoogle Scholar
  24. 24.
    Wang HY, Chu X, Zhao ZX, He XS, Guo YL (2011) J Chromatogr B 879:1166–1179CrossRefGoogle Scholar
  25. 25.
    Fuchs B, Schiller J (2009) Eur J Lipid Sci Technol 111:83–98CrossRefGoogle Scholar
  26. 26.
    Fuchs B, Schiller J (2009) Curr Org Chem 13:1664–1681CrossRefGoogle Scholar
  27. 27.
    Johnson BFG, McIndoe JS (2000) Coord Chem Rev 200:901–932CrossRefGoogle Scholar
  28. 28.
    Montaudo G, Samperi F, Montaudo MS (2006) Prog Polym Sci 31:277–357CrossRefGoogle Scholar
  29. 29.
    Crecelius AC, Baumgaertel A, Schubert US (2009) J Mass Spectrom 44:1277–1286CrossRefGoogle Scholar
  30. 30.
    Eelman MD, Moriarty MM, Fogg DE (2006) Educ Adv Chem 10:213–234Google Scholar
  31. 31.
    Mitra S (2003) Sample preparation techniques in analytical chemistry. Wiley, HobokenCrossRefGoogle Scholar
  32. 32.
    Prakash C, Shaffer CL, Nedderman A (2007) Mass Spectrom Rev 26:340–369CrossRefGoogle Scholar
  33. 33.
    Toyo'oka T (1999) Modern derivatization methods for separation sciences. Wiley, ChichesterGoogle Scholar
  34. 34.
    Zaikin V, Halket JM (2009) A handbook of derivatives for mass spectrometry. IM Publications, ChichesterGoogle Scholar
  35. 35.
    Chapman JR (1995) Encyclopedia of analytical science. Academic, LondonGoogle Scholar
  36. 36.
    Raynie DE (2004) Anal Chem 76:4659–4664CrossRefGoogle Scholar
  37. 37.
    Laiko VV, Baldwin MA, Burlingame AL (2000) Anal Chem 72:652–657CrossRefGoogle Scholar
  38. 38.
    Doroshenko VM, Laiko VV, Taranenko NI, Berkout VD, Lee HS (2002) Int J Mass Spectrom 221:39–58CrossRefGoogle Scholar
  39. 39.
    Su AK, Lin CH (2006) Talanta 68:673–678CrossRefGoogle Scholar
  40. 40.
    Berkenkamp S, Kirpekar F, Hillenkamp F (1998) Science 281:260–262CrossRefGoogle Scholar
  41. 41.
    Zenobi R, Knochenmuss R (1998) Mass Spectrom Rev 17:337–366CrossRefGoogle Scholar
  42. 42.
    Fitzgerald MC, Parr GR, Smith LM (1993) Anal Chem 65:3204–3211CrossRefGoogle Scholar
  43. 43.
    Knochenmuss R, Zenobi R (2003) Chem Rev 103:441–452CrossRefGoogle Scholar
  44. 44.
    Knochenmuss R (2006) Analyst 131:966–986CrossRefGoogle Scholar
  45. 45.
    Bailes J, Vidal L, Ivanov DA, Soloviev M (2009) J Nanobiotechnology 7:10CrossRefGoogle Scholar
  46. 46.
    Wei J, Buriak JM, Siuzdak G (1999) Nature 399:243–246CrossRefGoogle Scholar
  47. 47.
    Nayak R, Knapp DR (2010) Anal Chem 82:7772–7778CrossRefGoogle Scholar
  48. 48.
    Tarui A, Kawasaki H, Taiko T, Watanabe T, Yonezawa T, Arakawa R (2009) J Nanosci Nanotechnol 9:159–164CrossRefGoogle Scholar
  49. 49.
    Bi H, Qiao L, Busnel JM, Devaud V, Liu B, Girault HH (2009) Anal Chem 81:1177–1183CrossRefGoogle Scholar
  50. 50.
    Daniels RH, Dikler S, Li E, Stacey C (2008) J Assoc Lab Automation 13:314–321CrossRefGoogle Scholar
  51. 51.
    Yao T, Kawasaki H, Watanabe T, Arakawa R (2010) Int J Mass spectrom 291:145–151CrossRefGoogle Scholar
  52. 52.
    Dutta TK, Harayama S (2001) Anal Chem 73:864–869CrossRefGoogle Scholar
  53. 53.
    Kalberer M, Paulsen D, Sax M, Steinbacher M, Dommen J, Prevot ASH, Fisseha R, Weingartner E, Frankevich V, Zenobi R, Baltensperger U (2004) Science 303:1659–1662CrossRefGoogle Scholar
  54. 54.
    Gnaser H, Savina MR, Calaway WF, Tripa CE, Veryovkin IV, Pellin MJ (2005) Int J Mass spectrom 245:61–67CrossRefGoogle Scholar
  55. 55.
    Trimpin S, Herath TN, Inutan ED, Wager-Miller J, Kowalski P, Claude E, Walker JM, Mackie K (2009) Anal Chem 82:359–367CrossRefGoogle Scholar
  56. 56.
    Becker JS, Dietze HJ (2000) Int J Mass spectrom 197:1–35CrossRefGoogle Scholar
  57. 57.
    Annesley TM (2003) Clin Chem 49:1041–1044CrossRefGoogle Scholar
  58. 58.
    Fuchs B, Süß R, Nimptsch A, Schiller J (2009) Chromatographia 69:95–105CrossRefGoogle Scholar
  59. 59.
    Hillenkamp F, Karas M, Beavis RC, Chait BT (1991) Anal Chem 63:1193A–1203AGoogle Scholar
  60. 60.
    Hardouin J (2007) Mass Spectrom Rev 26:672–682CrossRefGoogle Scholar
  61. 61.
    McComb ME, Perlman DH, Huang H, Costello CE (2007) Rapid Commun Mass Spectrom 21:44–58CrossRefGoogle Scholar
  62. 62.
    Dunphy JC, Busch KL, Hettich RL, Buchanan MV (1993) Anal Chem 65:1329–1335CrossRefGoogle Scholar
  63. 63.
    Bogan MJ, Agnes GR (2004) Rapid Commun Mass Spectrom 18:2673–2681CrossRefGoogle Scholar
  64. 64.
    Therisod H, Labas V, Caroff M (2001) Anal Chem 73:3804–3807CrossRefGoogle Scholar
  65. 65.
    Rejtar T, Hu P, Juhasz P, Campbell JM, Vestal ML, Preisler J, Karger BL (2002) J Proteome Res 1:171–179CrossRefGoogle Scholar
  66. 66.
    Preisler J, Foret F, Karger BL (1998) Anal Chem 70:5278–5287CrossRefGoogle Scholar
  67. 67.
    Ørsnes H, Graf T, Degn H, Murray KK (2000) Anal Chem 72:251–254CrossRefGoogle Scholar
  68. 68.
    Guo Z, Zhang QC, Zou HF, Guo BC, Ni JY (2002) Anal Chem 74:1637–1641CrossRefGoogle Scholar
  69. 69.
    Welker M, Fastner J, Erhard M, Von Dohren H (2002) Environ Toxicol 17:367–374CrossRefGoogle Scholar
  70. 70.
    Grant GA, Frison SL, Yeung J, Vasanthan T, Sporns P (2003) J Agric Food Chem 51:6137–6144CrossRefGoogle Scholar
  71. 71.
    Yang HM, Wang JW, Song FR, Zhou YH, Liu SY (2011) Anal Chim Acta 701:45–51CrossRefGoogle Scholar
  72. 72.
    Ayorinde FO, Elhilo E, Hlongwane C (1999) Rapid Commun Mass Spectrom 13:737–739CrossRefGoogle Scholar
  73. 73.
    Ayorinde FO, Garvin K, Saeed K (2000) Rapid Commun Mass Spectrom 14:608–615CrossRefGoogle Scholar
  74. 74.
    Kaltashov IA, Doroshenko V, Cotter RJ, Takayama K, Qureshi N (1997) Anal Chem 69:2317–2322CrossRefGoogle Scholar
  75. 75.
    Harvey DJ (1995) J Mass Spectrom 30:1333–1346CrossRefGoogle Scholar
  76. 76.
    Al-Saad KA, Zabrouskov V, Siems WF, Knowles NR, Hannan RM, Hill HH Jr (2003) Rapid Commun Mass Spectrom 17:87–96CrossRefGoogle Scholar
  77. 77.
    Griffiths WJ, Liu S, Alvelius G, Sjövall J (2003) Rapid Commun Mass Spectrom 17:924–935CrossRefGoogle Scholar
  78. 78.
    Griffiths WJ (2003) Mass Spectrom Rev 22:81–152CrossRefGoogle Scholar
  79. 79.
    Tholey A, Heinzle E (2006) Anal Bioanal Chem 386:24–37CrossRefGoogle Scholar
  80. 80.
    Pan CS, Xu SY, Zhou H, Fu Y, Ye ML, Zou HF (2007) Anal Bioanal Chem 387:193–204CrossRefGoogle Scholar
  81. 81.
    van Kampen JJA, Burgers PC, de Groot R, Luider TM (2006) Anal Chem 78:5403–5411CrossRefGoogle Scholar
  82. 82.
    Ayorinde FO, Hambright P, Porter TN, Keith QL Jr (1999) Rapid Commun Mass Spectrom 13:2474–2479CrossRefGoogle Scholar
  83. 83.
    Zhang S, Liu JA, Chen Y, Xiong SX, Wang GH, Chen J, Yang GQ (2010) J Am Soc Mass Spectrorm 21:154–160CrossRefGoogle Scholar
  84. 84.
    Li YL, Gross ML (2004) J Am Soc Mass Spectrom 15:1833–1837CrossRefGoogle Scholar
  85. 85.
    Santos LS, Haddad R, Höehr NF, Pilli RA, Eberlin MN (2004) Anal Chem 76:2144–2147CrossRefGoogle Scholar
  86. 86.
    Catharino RR, de Azevedo Marques L, Santos LS, Baptista AS, Glória EM, Calori-Domingues MA, Facco EMP, Eberlin MN (2005) Anal Chem 77:8155–8157CrossRefGoogle Scholar
  87. 87.
    Ham BM, Jacob JT, Cole RB (2005) Anal Chem 77:4439–4447CrossRefGoogle Scholar
  88. 88.
    Laremore TN, Zhang FM, Linhardt RJ (2007) Anal Chem 79:1604–1610CrossRefGoogle Scholar
  89. 89.
    Shen ZX, Thomas JJ, Averbuj C, Broo KM, Engelhard M, Crowell JE, Finn MG, Siuzdak G (2001) Anal Chem 73:612–619CrossRefGoogle Scholar
  90. 90.
    Li XH, Wu X, Kim JM, Kim SS, Jin M, Li DH (2009) J Am Soc Mass Spectrom 20:2167–2173CrossRefGoogle Scholar
  91. 91.
    Xu SY, Li YF, Zou HF, Qiu JS, Guo Z, Guo BC (2003) Anal Chem 75:6191–6195CrossRefGoogle Scholar
  92. 92.
    Ren SF, Zhang L, Cheng ZH, Guo YL (2005) J Am Soc Mass Spectrom 16:333–339CrossRefGoogle Scholar
  93. 93.
    Ren SF, Guo YL (2005) Rapid Commun Mass Spectrom 19:255–260CrossRefGoogle Scholar
  94. 94.
    Zhang J, Wang HY, Guo YL (2005) Chin J Chem 23:185–189CrossRefGoogle Scholar
  95. 95.
    Wang CH, Li J, Yao SJ, Guo YL, Xia XH (2007) Anal Chim Acta 604:158–164CrossRefGoogle Scholar
  96. 96.
    Ren SF, Guo YL (2006) J Am Soc Mass Spectrom 17:1023–1027CrossRefGoogle Scholar
  97. 97.
    Dong XL, Cheng JS, Li JH, Wang YS (2010) Anal Chem 82:6208–6214CrossRefGoogle Scholar
  98. 98.
    Lu MH, Lai YQ, Chen GN, Cai ZW (2011) Anal Chem 83:3161–3169CrossRefGoogle Scholar
  99. 99.
    Tholey A, Wittmann C, Kang MJ, Bungert D, Hollemeyer K, Heinzle E (2002) J Mass Spectrom 37:963–973CrossRefGoogle Scholar
  100. 100.
    Adamczyk M, Gebler JC, Wu J (1999) Rapid Commun Mass Spectrom 13:1413–1422CrossRefGoogle Scholar
  101. 101.
    Lee PJ, Chen WB, Gebler JC (2004) Anal Chem 76:4888–4893CrossRefGoogle Scholar
  102. 102.
    Denekamp C, Lacour J, Laleu B, Rabkin E (2008) J Mass Spectrom 43:623–627CrossRefGoogle Scholar
  103. 103.
    Schiewek R, Mönnikes R, Wulf V, Gäb S, Brockmann KJ, Benter T, Schmitz OJ (2008) Angew Chem Int Ed 47:9989–9992CrossRefGoogle Scholar
  104. 104.
    Zhang J, Guo YL (2005) Rapid Commun Mass Spectrom 19:2461–2464CrossRefGoogle Scholar
  105. 105.
    Zhang J, Zhang L, Zhou Y, Guo YL (2007) J Mass Spectrom 42:1514–1521CrossRefGoogle Scholar
  106. 106.
    Fang F, Zhang J, Zhang L, Guo YL (2009) Chin J Chem 27:2397–2404CrossRefGoogle Scholar
  107. 107.
    Fang F, Liu P, Wang HY, Zhang L, Zhang J, Gao YP, Zeng LM, Guo YL (2009) Rapid Commun Mass Spectrom 23:1703–1709CrossRefGoogle Scholar
  108. 108.
    Wang H, Wang HY, Zhang L, Zhang J, Guo YL (2011) Anal Chim Acta 690:1–9CrossRefGoogle Scholar
  109. 109.
    Wang H, Wang HY, Zhang L, Zhang J, Leng JP, Cai TT, Guo YL (2011) Anal Chim Acta 707:100–106CrossRefGoogle Scholar
  110. 110.
    Zaia J (2004) Mass Spectrom Rev 23:161–227CrossRefGoogle Scholar
  111. 111.
    Gouw JW, Burgers PC, Trikoupis MA, Terlouw JK (2002) Rapid Commun Mass Spectrom 16:905–912CrossRefGoogle Scholar
  112. 112.
    Naven TJP, Harvey DJ (1996) Rapid Commun Mass Spectrom 10:829–834CrossRefGoogle Scholar
  113. 113.
    Okamoto M, Takahashi K, Doi T, Takimoto Y (1997) Anal Chem 69:2919–2926CrossRefGoogle Scholar
  114. 114.
    Broberg S, Broberg A, Duus JØ (2000) Rapid Commun Mass Spectrom 14:1801–1805CrossRefGoogle Scholar
  115. 115.
    Zhang XW, Wei D, Yap YL, Li L, Guo SY, Chen F (2007) Mass Spectrom Rev 26:403–431CrossRefGoogle Scholar
  116. 116.
    Dettmer K, Aronov PA, Hammock BD (2007) Mass Spectrom Rev 26:51–78CrossRefGoogle Scholar
  117. 117.
    Han XL, Gross RW (2005) Mass Spectrom Rev 24:367–412CrossRefGoogle Scholar
  118. 118.
    Nicholson JK, Lindon JC, Holmes E (1999) Xenobiotica 29:1181–1189CrossRefGoogle Scholar
  119. 119.
    Smith CA, O'Maille G, Want EJ, Qin C, Trauger SA, Brandon TR, Custodio DE, Abagyan R, Siuzdak G (2005) Ther Drug Monit 27:747–751CrossRefGoogle Scholar
  120. 120.
    Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G (2006) Anal Chem 78:779–787CrossRefGoogle Scholar
  121. 121.
    Brown SC, Kruppa G, Dasseux JL (2005) Mass Spectrom Rev 24:223–231CrossRefGoogle Scholar
  122. 122.
    Northen TR, Yanes O, Northen MT, Marrinucci D, Uritboonthai W, Apon J, Golledge SL, Nordström A, Siuzdak G (2007) Nature 449:1033–1036CrossRefGoogle Scholar
  123. 123.
    Woo HK, Northern TR, Yanes O, Siuzdak G (2008) Nat Protoc 3:1341–1349CrossRefGoogle Scholar
  124. 124.
    Wenk MR (2005) Nat Rev Drug Discov 4:594–610CrossRefGoogle Scholar
  125. 125.
    Murphy RC, Fiedler J, Hevko J (2001) Chem Rev 101:479–526CrossRefGoogle Scholar
  126. 126.
    Fuchs B, Schiller J (2008) Subcell Biochem 49:541–565CrossRefGoogle Scholar
  127. 127.
    Gross RW, Han X (2007) Methods Enzymol 433:73–90CrossRefGoogle Scholar
  128. 128.
    Schiller J, Suss R, Fuchs B, Muller M, Zschornig O, Arnold K (2007) Front Biosci 12:2568–2579CrossRefGoogle Scholar
  129. 129.
    Murphy RC, Hankin JA, Barkley RM (2008) J Lipid Res 50:S317–S322CrossRefGoogle Scholar
  130. 130.
    Yetukuri L, Ekroos K, Vidal-Puig A, Oresic M (2008) Mol Biosyst 4:121–217CrossRefGoogle Scholar
  131. 131.
    Greis KD (2007) Mass Spectrom Rev 26:324–339CrossRefGoogle Scholar
  132. 132.
    de Boer AR, Lingeman H, Niessen WMA, Irth H (2007) TrAc, Trends Anal Chem 26:867–883CrossRefGoogle Scholar
  133. 133.
    Houston CT, Taylor WP, Widlanski TS, Reilly JP (2000) Anal Chem 72:3311–3319CrossRefGoogle Scholar
  134. 134.
    Nichols KP, Gardeniers HJGE (2007) Anal Chem 79:8699–8704CrossRefGoogle Scholar
  135. 135.
    Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ (2001) Toxicol Appl Pharmacol 176:73–80CrossRefGoogle Scholar
  136. 136.
    Hu LG, Jiang GB, Xu SY, Pan CS, Zou HF (2006) J Am Soc Mass Spectrom 17:1616–1619CrossRefGoogle Scholar
  137. 137.
    Persike M, Zimmermann M, Klein J, Karas M (2010) Anal Chem 82:922–929CrossRefGoogle Scholar
  138. 138.
    Xu Z, Yao SJ, Wei YL, Zhou J, Zhang L, Wang CH, Guo YL (2008) J Am Soc Mass Spectrom 19:1849–1855CrossRefGoogle Scholar
  139. 139.
    Cai TT, Zhang L, Wang HY, Zhang J, Guo YL (2011) Anal Chim Acta 706:291–296CrossRefGoogle Scholar
  140. 140.
    Northen TR, Lee JC, Hoang L, Raymond J, Hwang DR, Yannone SM, Wong CH, Siuzdak G (2008) Proc Natl Acad Sci USA 105:3678–3683CrossRefGoogle Scholar
  141. 141.
    Yanes O, Villanueva J, Querol E, Aviles FX (2005) Mol Cell Proteomics 4:1602–1613CrossRefGoogle Scholar
  142. 142.
    Kondo N, Nishimura SI (2009) Chem Eur J 15:1413–1421CrossRefGoogle Scholar
  143. 143.
    Xu Z, Wang HY, Huang SX, Wei YL, Yao SJ, Guo YL (2010) Anal Chem 82:2113–2118CrossRefGoogle Scholar
  144. 144.
    Caprioli RM, Farmer TB, Gile J (1997) Anal Chem 69:4751–4760CrossRefGoogle Scholar
  145. 145.
    Luxemborg SL, Mize TH, McDonnell LA, Heeren RMA (2004) Anal Chem 76:5339–5344CrossRefGoogle Scholar
  146. 146.
    Reyzer ML, Chaurand P, Angel PM, Caprioli RM (2010) Methods Mol Biol 656:285–301CrossRefGoogle Scholar
  147. 147.
    Reyzer ML, Caprioli RM (2007) Curr Opin Chem Biol 11:29–35CrossRefGoogle Scholar
  148. 148.
    Hsieh YS, Korfmacher WA (2008) MALDI imaging mass spectrometry for direct tissue analysis of pharmaceuticals. In: Ramanathan R (ed) Mass spectrometry in drug metabolism and pharmacokinetics. Wiley, Hoboken, pp 359–382CrossRefGoogle Scholar
  149. 149.
    Reyzer ML, Hsieh Y, Ng K, Korfmacher WA, Caprioli RM (2003) J Mass Spectrom 38:1081–1092CrossRefGoogle Scholar
  150. 150.
    Grove KJ, Frappier SL, Caprioli RM (2011) J Am Soc Mass Spectrom 22:192–195CrossRefGoogle Scholar
  151. 151.
    Khabit-Shahidi S, Andersson M, Herman JL, Gillespie TA, Caprioli RM (2006) Anal Chem 78:6448–6456CrossRefGoogle Scholar
  152. 152.
    Puolitaival SM, Burnum KE, Cornett DS, Caprioli RM (2008) J Am Soc Mass Spectrom 19:882–886CrossRefGoogle Scholar
  153. 153.
    Garden RW, Sweedler JV (2000) Anal Chem 72:30–36CrossRefGoogle Scholar
  154. 154.
    Hsieh Y, Casale R, Fukuda E, Chen JW, Knemeyer I, Wingate J, Morrison R, Korfmacher W (2006) Rapid Commun Mass Spectrom 20:965–972CrossRefGoogle Scholar
  155. 155.
    Amantionico A, Zenobi R (2006) 17th international mass spectrometry conference, Prague, 27th August to 1st September 2006Google Scholar
  156. 156.
    Jackson SN, Wang HY, Woods AS, Ugarov M, Egan T, Schultz JA (2005) J Am Soc Mass Spectrom 16:133–138CrossRefGoogle Scholar
  157. 157.
    Woods AS, Ugarov M, Jackson SN, Egan T, Wang HY, Murray KK, Schultz JA (2006) J Preoteome Res 5:1484–1487CrossRefGoogle Scholar
  158. 158.
    McLean JA, Ridenour WB, Caprioli RM (2007) J Mass Spectrom 42:1099–1105CrossRefGoogle Scholar
  159. 159.
    Korfmacher WA (2005) Bioanalytical assays in a drug discovery environment. In: Using mass spectrometry for drug metabolism studies. CRC, Boca Raton, pp 1–34Google Scholar
  160. 160.
    Korfmacher WA (2010) Using mass spectrometry for drug metabolism studies, 2nd edn. CRC, Boca Raton, p 429Google Scholar
  161. 161.
    Franck J, El Ayed M, Wisztorski M, Salzet M, Fournier I (2009) Anal Chem 81:8305–8317CrossRefGoogle Scholar
  162. 162.
    Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O (2011) J Mass Spectrom 46:840–846CrossRefGoogle Scholar
  163. 163.
    Traeger JC (2000) Int J Mass Spectrom 200:387–401CrossRefGoogle Scholar
  164. 164.
    Henderson W, Mcindoe SJ (2005) Mass spectrometry of inorganic and organometallic compounds: tools techniques tips. Wiley, ChichesterCrossRefGoogle Scholar
  165. 165.
    Ulmer L, Mattay J, Torres-Garcia HG, Luftmann H (2000) Eur J Mass Spectrom 6:49–52CrossRefGoogle Scholar
  166. 166.
    Brown T, Clipston NL, Simjee N, Luftmann H, Hungerbühler H, Drewello T (2001) Int J Mass Spectrom 210:249–263CrossRefGoogle Scholar
  167. 167.
    Lou X, van Buijtenen J, Bastiaansen JJAM, de Waal BFM, Langeveld BMW, van Dongen JLJ (2005) J Mass Spectrom 40:654–660CrossRefGoogle Scholar
  168. 168.
    Wyatt MF, Stein BK, Brenton AG (2006) Anal Chem 78:199–206CrossRefGoogle Scholar
  169. 169.
    Hughes L, Wyatt MF, Stein BK, Brenton AG (2009) Anal Chem 81:543–550CrossRefGoogle Scholar
  170. 170.
    Lou XW, de Waal BFM, van Dongen JLJ, Vekemans JAJM, Meijer EW (2010) J Mass Spectrom 45:1195–1202CrossRefGoogle Scholar
  171. 171.
    Lubben AT, McIndoe JS, Weller AS (2008) Organometallics 27:3303–3306CrossRefGoogle Scholar
  172. 172.
    Ham JE, Durham B, Scott JR (2003) J Am Soc Mass Spectrom 14:393–400CrossRefGoogle Scholar
  173. 173.
    Eelman MD, Blacquiere JM, Moriarty MM, Fogg DE (2008) Angew Chem Int Ed 47:303–306CrossRefGoogle Scholar
  174. 174.
    Trimpin S (2007) In: Gross ML, Caprioli RM (eds) Encyclopedia of mass spectrometry, vol 6. Elsevier, New York, p 683Google Scholar
  175. 175.
    Montaudo G, Carroccio S, Puglisi C (2002) J Anal Appl Pyrol 64:229–247CrossRefGoogle Scholar
  176. 176.
    Monfette S, Fogg DE (2006) Organometallics 25:1940–1944CrossRefGoogle Scholar
  177. 177.
    Monfette S, Duarte Silva JA, Gorelsky SI, Dalgarno SJ, dos Santos EN, Araujo MH, Fogg DE (2009) Can J Chem 87:361–367CrossRefGoogle Scholar
  178. 178.
    de Frémont P, Stevens ED, Eelman MD, Fogg DE, Nolan SP (2006) Organometallics 25:5824–5828CrossRefGoogle Scholar
  179. 179.
    Juhasz P, Costello CE (1993) Rapid Commun Mass Spectrom 7:343–351CrossRefGoogle Scholar
  180. 180.
    Lidgard R, Duncan MW (1995) Rapid Commun Mass Spectrom 9:128–132CrossRefGoogle Scholar
  181. 181.
    McCarley TD, McCarley RL, Limbach PA (1998) Anal Chem 70:4376–4379CrossRefGoogle Scholar
  182. 182.
    Macha SF, McCarley TD, Limbach PA (1999) Anal Chim Acta 397:235–245CrossRefGoogle Scholar
  183. 183.
    Vasil’ev YV, Khvostenko OG, Streletskii AV, Boltalina OV, Kotsiris SG, Drewello T (2006) J Phys Chem A 110:5967–5972CrossRefGoogle Scholar
  184. 184.
    Wyatt MF, Havard S, Stein BK, Brenton AG (2008) Rapid Commun Mass Spectrom 22:11–18CrossRefGoogle Scholar
  185. 185.
    Wyatt MF, Stein BK, Brenton AG (2006) J Am Soc Mass Spectrom 17:672–675CrossRefGoogle Scholar
  186. 186.
    Griffiths NW, Wyatt MF, Kean SD, Graham AE, Stein BK, Brenton AG (2010) Rapid Commun Mass Spectrom 24:1629–1635CrossRefGoogle Scholar
  187. 187.
    Wyatt MF, Ding S, Stein BK, Brenton AG, Daniels RH (2010) J Am Soc Mass Spectrom 21:1256–1259CrossRefGoogle Scholar
  188. 188.
    Ikpo N, Butt SM, Collins KL, Kerton FM (2009) Organometallics 28:837–842CrossRefGoogle Scholar
  189. 189.
    Ghiladi RA, Huang H, Moenne-Laccoz P, Stasser J, Blackburn NJ, Woods AS, Cotter RJ, Incarvito CD, Rheingold AL, Karlin KD (2005) J Biol Inorg Chem 10:63–77CrossRefGoogle Scholar
  190. 190.
    Michalak L, Fisher KJ, Alderdice DS, Jardine DR, Willett GD (1994) Org Mass Spectrom 29:512–515CrossRefGoogle Scholar
  191. 191.
    Bai YP, Liu S, Song FR, Liu ZQ, Liu SY (2012) Rapid Commun Mass Spectrom 26:715–718CrossRefGoogle Scholar
  192. 192.
    Brune DC (1999) Rapid Commun Mass Spectrom 13:384–389CrossRefGoogle Scholar
  193. 193.
    Zhu W, Wang HY, Guo YL (2012) J Mass Spectrom 47:352–354CrossRefGoogle Scholar
  194. 194.
    Petković M, Petrović B, Savić J, Bugarčić ŽD, Dimitrić-Marković J, Momić T, Vasić V (2010) Int J Mass Spectrom 290:39–46CrossRefGoogle Scholar
  195. 195.
    Liu JS, Loewe RS, McCullough RD (1999) Macromolecules 32:5777–5785CrossRefGoogle Scholar
  196. 196.
    Puglisi C, Samperi F, Alicata R, Montaudo G (2002) Macromolecules 35:3000–3007CrossRefGoogle Scholar
  197. 197.
    Zhou GC, Harruna II (2007) Anal Chem 79:2722–2727CrossRefGoogle Scholar
  198. 198.
    Kostjuk SV, Ortega E, Ganachaud F, Améduri B, Boutevin B (2009) Macromolecules 42:612–619CrossRefGoogle Scholar
  199. 199.
    Mizutani M, Satoh K, Kamigaito M (2010) J Am Chem Soc 132:7498–7507CrossRefGoogle Scholar
  200. 200.
    Scherman OA, Rutenberg IM, Grubbs RH (2003) J Am Chem Soc 125:8515–8522CrossRefGoogle Scholar
  201. 201.
    Martinez V, Blais JC, Bravic G, Astruc D (2004) Organometallics 23:861–874CrossRefGoogle Scholar
  202. 202.
    Petkovska VI, Hopkins TE, Powell DH, Wagener KB (2005) Macromolecules 38:5878–5885CrossRefGoogle Scholar
  203. 203.
    Petkovska VI, Hopkins TE, Powell DH, Wagener KB (2006) Anal Chem 78:3624–3631CrossRefGoogle Scholar
  204. 204.
    Mason BP, Price KE, Steinbacher JL, Bogdan AR, McQuade DT (2007) Chem Rev 107:2300–2318CrossRefGoogle Scholar
  205. 205.
    McMullen JP, Jensen KF (2010) Ann Rev Anal Chem 3:19–42CrossRefGoogle Scholar
  206. 206.
    Hatakeyama T, Chen DL, Ismagilov RF (2006) J Am Chem Soc 128:2518–2519CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Shanghai Mass Spectrometry Center, Shanghai Institute of Organic ChemistryChinese Academy of ScienceShanghaiPeople’s Republic of China

Personalised recommendations