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Dynamic Nuclear Polarization: New Methodology and Applications

  • Kong Hung Sze
  • Qinglin Wu
  • Ho Sum Tse
  • Guang Zhu
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 326)

Abstract

One way to overcome the intrinsically low sensitivity of Nuclear Magnetic Resonance spectroscopy is to enhance the signal by dynamic nuclear polarization (DNP), where the polarization of high-gyromagnetic ratio (γ) electrons is transferred to the surrounding nuclei using microwave (MW) irradiation. Recent developments in DNP instrumentations and applications have shown that DNP is one of the most effective methods to increase the nuclear spin polarization in inorganic, organic, and biological materials. It is possible to obtain a solution of molecules containing hyperpolarized nuclei in combination with methods to dissolve rapidly the polarized solid sample. In this chapter, a brief introduction on a theoretical basis and some of new DNP applications in NMR spectroscopy as well as medical applications in Magnetic Resonance Imaging (MRI) are described.

Keywords

DNP NMR MRIh 

Notes

Acknowledgements

This research work was supported by grants from Hong Kong Research Grants Council (RGC664109, RGC775508, and RGC776509), AoE/M-06/08, TUYF10SC03, SEG/CUHK09, SEG_HKUST06, and HKUST Research Fund.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of MicrobiologyThe University of Hong KongHong KongChina
  2. 2.Division of Life ScienceThe Hong Kong University of Science and TechnologyKowloon, Hong KongChina

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