Dynamic Nanoplatforms in Biosensor and Membrane Constitutional Systems

Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 322)

Abstract

Molecular recognition in biological systems occurs mainly at interfacial environments such as membrane surfaces, enzyme active sites, or the interior of the DNA double helix. At the cell membrane surface, carbohydrate–protein recognition principles apply to a range of specific non-covalent interactions including immune response, cell proliferation, adhesion and death, cell–cell interaction and communication. Protein–protein recognition meanwhile accounts for signalling processes and ion channel structure. In this chapter we aim to describe such constitutional dynamic interfaces for biosensing and membrane transport applications. Constitutionally adaptive interfaces may mimic the recognition capabilities intrinsic to natural recognition processes. We present some recent examples of 2D and 3D constructed sensors and membranes of this type and describe their sensing and transport capabilities.

Keywords

Bilayers Biosensor Constitutional dynamic chemistry Dynamic interfaces Nanoparticles Quartz crystal microgravimetry Surface plasmon resonance 

Abbreviations

Con A

Concanavalin A

Gb3

Globotriaosylceramide

GM1

Monosialotetrahexosylganglioside

HBM

Hybrid bilayer membrane

MIP

Molecularly imprinted polymer

NP

Nanoparticle

QCM

Quartz crystal microbalance

SAM

Self assembled monolayer

SERS

Surface Enhanced Raman Spectroscopy

SPR

Surface plasmon resonance

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Institut Européen des Membranes – ENSCM-UMII-CNRS 5635Montpellier, Cedex 5France
  2. 2.Attana ABStockholmSweden

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