Constitutional Dynamic Chemistry

Volume 322 of the series Topics in Current Chemistry pp 139-163


Dynamic Nanoplatforms in Biosensor and Membrane Constitutional Systems

  • Eugene MahonAffiliated withInstitut Européen des Membranes – ENSCM-UMII-CNRS 5635
  • , Teodor AastrupAffiliated withAttana AB
  • , Mihail BarboiuAffiliated withInstitut Européen des Membranes – ENSCM-UMII-CNRS 5635 Email author 

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Molecular recognition in biological systems occurs mainly at interfacial environments such as membrane surfaces, enzyme active sites, or the interior of the DNA double helix. At the cell membrane surface, carbohydrate–protein recognition principles apply to a range of specific non-covalent interactions including immune response, cell proliferation, adhesion and death, cell–cell interaction and communication. Protein–protein recognition meanwhile accounts for signalling processes and ion channel structure. In this chapter we aim to describe such constitutional dynamic interfaces for biosensing and membrane transport applications. Constitutionally adaptive interfaces may mimic the recognition capabilities intrinsic to natural recognition processes. We present some recent examples of 2D and 3D constructed sensors and membranes of this type and describe their sensing and transport capabilities.


Bilayers Biosensor Constitutional dynamic chemistry Dynamic interfaces Nanoparticles Quartz crystal microgravimetry Surface plasmon resonance