Dynamic Combinatorial Self-Replicating Systems

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 322)


Thanks to their intrinsic network topologies, dynamic combinatorial libraries (DCLs) represent new tools for investigating fundamental aspects related to self-organization and adaptation processes. Very recently the first examples integrating self-replication features within DCLs have pushed even further the idea of implementing dynamic combinatorial chemistry (DCC) towards minimal systems capable of self-construction and/or evolution. Indeed, feedback loop processes – in particular in the form of autocatalytic reactions – are keystones to build dynamic supersystems which could possibly approach the roots of “Darwinian” evolvability at mesoscale. This topic of current interest also shows significant potentialities beyond its fundamental character, because truly smart and autonomous materials for the future will have to respond to changes of their environment by selecting and by exponentially amplifying their fittest constituents.


Chemical evolution Dynamic combinatorial chemistry Self-replication Systems chemistry 



We wish to thank the European Research Council (ERC StG n° 257099), the Agence Nationale de la Recherche (ANR-09-BLAN-034-02), the CNRS, the icFRC, and the University of Strasbourg. We also acknowledge ESF-COST action on Systems Chemistry (CM0703).


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Copyright information

© Springer-Verlag Berlin-Heidelberg 2011

Authors and Affiliations

  1. 1.SAMS research group – icFRCUniversity of Strasbourg – Institut Charles Sadron, CNRSStrasbourg cedex 2France

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