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Fragment-Based Approaches and Computer-Aided Drug Discovery

  • Didier Rognan
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 317)

Abstract

Fragment-based design has significantly modified drug discovery strategies and paradigms in the last decade. Besides technological advances and novel therapeutic avenues, one of the most significant changes brought by this new discipline has occurred in the minds of drug designers. Fragment-based approaches have markedly impacted rational computer-aided design both in method development and in applications. The present review illustrates the importance of molecular fragments in many aspects of rational ligand design, and discusses how thinking in “fragment space” has boosted computational biology and chemistry.

Keywords

Docking Drug design Fragment Library 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Structural ChemogenomicsUMR 7200 CNRS-University of StrasbourgIllkirchFrance

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