Radicals in Synthesis III pp 33-59

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 320)

| Cite as

Modern Developments in Aryl Radical Chemistry

Chapter

Abstract

This review summarizes recent advances in the field of aryl radical chemistry. In particular, modern developments of the well-known Meerwein, Pschorr, and Gomberg–Bachmann reactions are presented along with new applications in natural product syntheses. Among the methods for the generation of aryl radicals, tin hydrides play a predominant role, but more and more attractive and promising alternatives are beginning to emerge.

Keywords

Aryl radicals Natural products Radical addition Radical cyclization 

Abbreviations

AIBN

Azo-bis(isobutyronitrile)

PTGB

Phase-transfer Gomberg–Bachmann

TEMPO

2,2,6,6-Tetramethylpiperidine-1-oxyl (radical)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Pharmazeutische Chemie, Department für Chemie und Pharmazie derFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

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