Lycopodium Alkaloids: Isolation and Asymmetric Synthesis

  • Mariko Kitajima
  • Hiromitsu Takayama
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 309)


Lycopodium alkaloids have attracted the attention of many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics. In this review we describe isolation and asymmetric syntheses of several new alkaloids such as lycoposerramines-C, -V, -W, and cernuine, and show that asymmetric total synthesis played a key role in elucidating the structures of these complex natural products.

Graphical Abstract


Alkaloid Asymmetric synthesis Isolation Lycopodium Structure elucidation 



Acetylcholine esterase




Carbonyl diimidazole


Diisopropyl azodicarboxylate


Dess–Martin periodinane


Diphenylphosphinyl azide




Di-tert-butyl azodicarboxylate


2-Iodoxybenzoic acid




N-Methylmorpholine oxide




Tris(dimethylamino)sulfonium difluorotrimethylsilicate




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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesChiba UniversityChibaJapan

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