Chapter

C-H Activation

Volume 292 of the series Topics in Current Chemistry pp 35-56

Date:

Mechanistic Considerations in the Development and Use of Azine, Diazine and Azole N-Oxides in Palladium-Catalyzed Direct Arylation

  • Keith FagnouAffiliated withDepartment of Chemistry, University of Ottawa Email author 

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Abstract

Azines, diazines or thiazole N-oxides are highly reactive substrates in palladium-catalyzed direct arylation reaction. For these reactions, the results are inconsistent with an SEAr reaction pathway and may best fit with a concerted metalation-deprotonation-like (CMD) mechanism.

Keywords

Direct arylation Palladium Catalysis Azines Azoles