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Nickel-Catalyzed Reductive Couplings of Aldehydes and Alkynes

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Metal Catalyzed Reductive C–C Bond Formation

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 279))

Abstract

The nickel-catalyzed coupling of aldehydes and alkynes has evolved into a broadly useful procedure for the preparation of allylic alcohols. An overview of the many variants of the process, illustrations of complex synthetic applications, and a discussion of mechanism is provided. Additionally, a brief summary of mechanistically related nickel-catalyzed processes as well as a description of alternate strategies for the reductive coupling of aldehydes and alkynes using other metals is provided.

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Authors and Affiliations

  1. Department of Chemistry, University of Michigan, 930 North University Avenue, 48109-1055, Ann Arbor, Michigan, USA

    John Montgomery & Grant J. Sormunen

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  1. John Montgomery
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  2. Grant J. Sormunen
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Correspondence to John Montgomery .

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Michael J. Krische

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Montgomery, J., Sormunen, G.J. (2007). Nickel-Catalyzed Reductive Couplings of Aldehydes and Alkynes. In: Krische, M.J. (eds) Metal Catalyzed Reductive C–C Bond Formation. Topics in Current Chemistry, vol 279. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2007_139

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