From Logical Regulatory Graphs to Standard Petri Nets: Dynamical Roles and Functionality of Feedback Circuits

  • Elisabeth Remy
  • Paul Ruet
  • Luis Mendoza
  • Denis Thieffry
  • Claudine Chaouiya
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4230)


Logical modelling and Petri nets constitute two complementary approaches for the dynamical modelling of biological regulatory networks. Leaning on a translation of logical models into standard Petri nets, we propose a formalisation of the notion of circuit functionality in the Petri net framework. This approach is illustrated with the modelling and analysis of a molecular regulatory network involved in the control of Th-lymphocyte differentiation.


genetic regulatory graphs Petri nets feedback circuit discrete dynamics qualitative analysis 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Elisabeth Remy
    • 1
  • Paul Ruet
    • 1
  • Luis Mendoza
    • 2
  • Denis Thieffry
    • 3
  • Claudine Chaouiya
    • 3
  1. 1.IML, Campus de LuminyMarseille Cedex 9France
  2. 2.Serono Pharmacological Research InstituteGenevaSwitzerland
  3. 3.LGPDMarseille Cedex 9France

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