BCM-Type Synaptic Plasticity Model Using a Linear Summation of Calcium Elevations as a Sliding Threshold
It has been considered that an amount of calcium elevation in a synaptic spine determines whether the synapse is potentiated or depressed. However, it has been pointed out that simple application of the principle can not reproduce properties of spike-timing-dependent plasticity (STDP). To solve the problem, we present a possible mechanism using dynamically sliding threshold as the linear summation of calcium elevations induced by single pre-synaptic and post-synaptic spikes. We demonstrate that the model can reproduce the timing dependence of biological STDP. In addition, we find that the model can reproduce the dependence of biological STDP on the initial synaptic strength, which is found to be asymmetric for synaptic potentiation and depression, whereas no explicit initial-strength dependence nor asymmetric mechanism are incorporated into the model.
KeywordsNMDA Receptor Synaptic Plasticity Synaptic Strength Synaptic Depression Calcium Elevation
Unable to display preview. Download preview PDF.
- 2.Bi, G.Q., Poo, M.: Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J. Neuroscience 18, 10464–10472 (1998)Google Scholar
- 9.Hebb, D.O.: The Organization of Behavior: A Neuropsychological Theory. Wiley, New York (1949)Google Scholar
- 11.Bienenstock, E., Cooper, L., Munro, P.: Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J. Neuroscience 2, 32–48 (1982)Google Scholar
- 26.van Rossum, M.C.W., Bi, G.Q., Turrigiano, G.G.: Stable hebbian learning from spike timing-dependent plasticity. J. Neuroscience 20, 8812–8821 (2000)Google Scholar
- 28.Gütig, R., Aharonov, R., Rotter, S., Sompolinsky, H.: Learning input correlations through nonlinear temporally asymmetric hebbian plasticity. J. Neuroscience 23, 3697–3714 (2003)Google Scholar