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Consistent and Elastic Registration of Histological Sections Using Vector-Spline Regularization

  • Ignacio Arganda-Carreras
  • Carlos O. S. Sorzano
  • Roberto Marabini
  • José María Carazo
  • Carlos Ortiz-de-Solorzano
  • Jan Kybic
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4241)

Abstract

Here we present a new image registration algorithm for the alignment of histological sections that combines the ideas of B-spline based elastic registration and consistent image registration, to allow simultaneous registration of images in two directions (direct and inverse). In principle, deformations based on B-splines are not invertible. The consistency term overcomes this limitation and allows registration of two images in a completely symmetric way. This extension of the elastic registration method simplifies the search for the optimum deformation and allows registering with no information about landmarks or deformation regularization. This approach can also be used as the first step to solve the problem of group-wise registration.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Ignacio Arganda-Carreras
    • 1
    • 3
  • Carlos O. S. Sorzano
    • 1
    • 5
  • Roberto Marabini
    • 1
    • 3
  • José María Carazo
    • 1
  • Carlos Ortiz-de-Solorzano
    • 2
  • Jan Kybic
    • 4
  1. 1.Biocomputing Unit, National Centre of BiotechnologyUniversidad Autónoma de MadridCantoblanco, MadridSpain
  2. 2.Cancer Imaging LaboratoryCentre for Applied Medical Research (CIMA)PamplonaSpain
  3. 3.Escuela Politécnica SuperiorUniversidad Autónoma de MadridMadridSpain
  4. 4.Center for Machine PerceptionCzech Technical UniversityPrague 2Czech Republic
  5. 5.Escuela Politécnica SuperiorUniv. San Pablo CEUMadridSpain

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