Solvent Effects and Conformational Stability of a Tripeptide

  • Maxim V. Fedorov
  • Stephan Schumm
  • Jonathan M. Goodman
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4216)


In this work we are trying to gain an insight on the molecular mechanisms of the salt effects on conformational stability of proteins with use of fully atomistic Molecular Dynamics simulations techniques. Such ‘in silico’ approach allows us to obtain quite realistic data on the time and scale resolutions that are unavailable for both ‘in vitro’ and ‘in vivo’ experimental techniques. We investigated a trialanine peptide which is the one of the simplest examples of biomolecules, bearing the essential features of proteins.


Conformational Stability Peptide Atom Compact Conformation Frequent Distance Chlorine Anion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Maxim V. Fedorov
    • 1
  • Stephan Schumm
    • 2
  • Jonathan M. Goodman
    • 1
  1. 1.Unilever Centre for Molecular Science Informatics, Department of ChemistryUniversity of CambridgeCambridgeUK
  2. 2.Unilever Food and Health Research Institute, Unilever R&D VlaardingenVlaardingenThe Netherlands

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