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Genetic Algorithm and Neural Network Based Classification in Microarray Data Analysis with Biological Validity Assessment

  • Vitoantonio Bevilacqua
  • Giuseppe Mastronardi
  • Filippo Menolascina
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4115)

Abstract

Microarrays allow biologists to better understand the interactions between diverse pathologic states at the gene level. However, the amount of data generated by these tools becomes problematic. New techniques are then needed in order to extract valuable information about gene activity in sensitive processes like tumor cells proliferation and metastasis activity. Recent tools that analyze microarray expression data have exploited correlation-based approach such as clustering analysis. Here we describe a novel GA/ANN based method for assessing the importance of genes for sample classification based on expression data. Several different approaches have been exploited and a com-parison has been given. The developed system has been employed in the classification of ER+/- metastasis recurrence of breast cancer tumours and results were validated using a real life database. Further validation has been carried out using Gene Ontology based tools. Results proved the valuable potentialities and robustness of similar systems.

Keywords

Genetic Algorithm Gene Ontology Artificial Immune System Microarray Data Analysis Soft Computing Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Vitoantonio Bevilacqua
    • 1
  • Giuseppe Mastronardi
    • 1
  • Filippo Menolascina
    • 1
  1. 1.Dipartimento di Elettrotecnica ed ElettronicaPolytechnic of BariBariItaly

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