Multi-scale Voxel-Based Morphometry Via Weighted Spherical Harmonic Representation
Although the voxel-based morphometry (VBM) has been widely used in quantifying the amount of gray matter of the human brain, the optimal amount of registration that should be used in VBM has not been addressed. In this paper, we present a novel multi-scale VBM using the weighted spherical harmonic (SPHARM) representation to address the issue. The weighted-SPHARM provides the explicit smooth functional representation of a true unknown cortical boundary. Based on this new representation, the gray matter tissue density is constructed using the Euclidean distance map from a voxel to the estimated smooth cortical boundary. The methodology is applied in localizing abnormal cortical regions in a group of autistic subjects.
KeywordsGray Matter Image Registration High Functioning Autistic Gray Matter Density Autistic Subject
Unable to display preview. Download preview PDF.
- 3.Chung, M.K., Shen, L., Dalton, K.M., Kelley, D.J., Robbins, S.M., Evans, A.C., Davidson, R.J.: Weighted spherical harmonic representation and its application to cortical analysis. Technical Report 1118. Dept. of Stat., University of Wisconsin-Madison, http://www.stat.wisc.edu/~mchung/papers/TR1118.2006.pdf
- 6.Gerig, G., Styner, M., Jones, D., Weinberger, D., Lieberman, J.: Shape analysis of brain ventricles using spharm. In: MMBIA, pp. 171–178 (2001)Google Scholar
- 10.Shen, L., Ford, J., Makedon, F., Saykin, A.: Surface-based approach for classification of 3d neuroanatomical structures. Intelligent Data Analysis 8 (2004)Google Scholar
- 11.Thompson, P.M., Hayashi, K.M., de Zubicaray, G., Janke, A.L., Rose, S.E., Semple, J., Herman, D., Hong, M.S., Dittmer, S.S., Doddrell, D.M., Toga, A.W.: Dynamics of gray matter loss in Alzheimer’s disease. Journal of Neuroscience 23, 994–1005 (2003)Google Scholar