An Integral Model of Spreading Depression: From Neuron Channels to Field Potentials

  • Ioulia Makarova
  • Iria R. Cepeda
  • Fivos Panetsos
  • Oscar Herreras
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3561)


Spreading depression is an inactivating wave of massive cell depolarization that moves slowly through the brain associated to large negative DC potentials. Its biophysical nature is unclear. Based on our recent finding that longitudinal depolarizing gradients arise on individual neurons affected by SD, we have initiated the construction of an integral model to reproduce large macroscopic potentials in the extracellular space from channel activity on individual neurons. The model includes a simulation of the extracellular space and features V o feedback to calculate transmembrane currents and potentials.


Model Neuron Dendritic Tree Spreading Depression Apical Tree Spreading Depression Wave 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  • Ioulia Makarova
    • 1
    • 2
  • Iria R. Cepeda
    • 1
    • 2
  • Fivos Panetsos
    • 2
  • Oscar Herreras
    • 1
  1. 1.Dept. Investigación Hospital Ramón y CajalMadridSpain
  2. 2.Dept. Matemática Aplicada, Fac. BiologíaUniversidad Complutense de MadridMadridSpain

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