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Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening

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Transportome Malfunction in the Cancer Spectrum

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 181))

Abstract

In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes in the expression of individual ion channels show a specific profile, making these proteins promising clinical biomarkers that may enable better molecular subtyping of the disease and lead to more rapid and accurate clinical decision-making. Expression profiles and channel function are mainly based on the tumoral tissue itself, in this case, the epithelial cancer cell population. To date, little data on the ion channel profile of the cancerous prostate stroma are available, even though tumor interactions with the microenvironment are crucial in carcinogenesis and each distinct population plays a specific role in tumor progression. In this review, we describe ion channel expression profiles specific for the distinct cell population of the tumor microenvironment (stromal, endothelial, neuronal, and neuroendocrine cell populations) and the technical approaches used for efficient separation and screening of these cell populations.

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Acknowledgments

English language, grammar, punctuation, spelling, and overall style by the highly qualified native English-speaking editors at American Journal Experts (certificate number EDCC-3B24-C703-F3F2-FDE9).

Conflict of Interest

The authors declare no conflict of interest in the manuscript.

Funding

All authors were supported by grants from the Ministère de l’Education Nationale, the Institut National de la Santé et de la Recherche Medicale (INSERM), and La Ligue contre le cancer. DG was supported by the Institut Universitaire de France (IUF). VF was supported by Institut National du Cancer (INCA).

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Authors and Affiliations

  1. Université de Lille, Inserm, U1003 – PHYCEL – Physiologie Cellulaire, Lille, France

    Valerio Farfariello, Natalia Prevarskaya & Dimitra Gkika

  2. Laboratory of Excellence, Ion Channels Science and Therapeutics, Université de Lille, Villeneuve d’Ascq, France

    Valerio Farfariello, Natalia Prevarskaya & Dimitra Gkika

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  1. Valerio Farfariello
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Correspondence to Dimitra Gkika .

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  1. Medizinische Hochschule Hannover, Zentrum für Innere Medizin, Hannover, Germany

    Christian Stock

  2. Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

    Luis A. Pardo

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Farfariello, V., Prevarskaya, N., Gkika, D. (2020). Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening. In: Stock, C., Pardo, L.A. (eds) Transportome Malfunction in the Cancer Spectrum. Reviews of Physiology, Biochemistry and Pharmacology, vol 181. Springer, Cham. https://doi.org/10.1007/112_2020_22

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