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Ezrin Orchestrates Signal Transduction in Airway Cells

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Reviews of Physiology, Biochemistry and Pharmacology Vol. 174

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 174))

Abstract

Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth factor receptor (EGFR), CD44, vascular cell adhesion molecule (VCAM), and the deleted in colorectal cancer (DCC) receptor. We also analyze the ezrin-meditated regulation of critical pathways associated with asthma, such as the RhoA, Rho-associated protein kinase (ROCK), and protein kinase A (cAMP/PKA) pathways. Mounting evidence suggests that ezrin plays a role in controlling airway cell function and potentially contributes to respiratory diseases. Ezrin can participate in asthma pathogenesis by affecting bronchial epithelium repair, T lymphocyte regulation, and the contraction of the airway smooth muscle cells. These studies provide new insights for the design of novel therapeutic strategies for asthma treatment.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81473760, 81574058); the Shanghai Talent Development Fund (No. 201610); the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (JZ2016010).

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Authors and Affiliations

  1. Laboratory of Molecular Biology, Shanghai Research Institute of Acupuncture and Meridian, Yue Yang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China

    Lei-Miao Yin, Ting-Ting Duan, Luis Ulloa & Yong-Qing Yang

  2. Department of Surgery, Center of Immunology and Inflammation, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ, 07101, USA

    Luis Ulloa

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  1. Lei-Miao Yin
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  2. Ting-Ting Duan
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  3. Luis Ulloa
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  4. Yong-Qing Yang
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Correspondence to Luis Ulloa or Yong-Qing Yang .

Editor information

Editors and Affiliations

  1. Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

    Bernd Nilius

  2. Heart Science Centre, The Magdi Yacoub Institute, Harefield, United Kingdom

    Pieter de Tombe

  3. Walther-Straub Institute for Pharmacology and Toxicology, Ludwig-Maximilians University of Munich, Munich, Germany

    Thomas Gudermann

  4. Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

    Reinhard Jahn

  5. Department of Cytobiology, University of Marburg , Marburg, Germany

    Roland Lill

  6. Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom

    Ole H. Petersen

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The authors declare that they have no conflicts of interest.

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Yin, LM., Duan, TT., Ulloa, L., Yang, YQ. (2017). Ezrin Orchestrates Signal Transduction in Airway Cells. In: Nilius, B., de Tombe, P., Gudermann, T., Jahn, R., Lill, R., Petersen, O. (eds) Reviews of Physiology, Biochemistry and Pharmacology Vol. 174. Reviews of Physiology, Biochemistry and Pharmacology, vol 174. Springer, Cham. https://doi.org/10.1007/112_2017_4

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