The “Sweet” Side of Ion Channels

  • Joanna Lazniewska
  • Norbert WeissEmail author
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 167)


Ion channels play a crucial role in cell functioning, contributing to transmembrane potential and participating in cell signalling and homeostasis. To fulfil highly specialised functions, cells have developed various mechanisms to regulate channel expression and activity at particular subcellular loci, and alteration of ion channel regulation can lead to serious disorders. Glycosylation, one of the most common forms of co- and post-translational protein modification, is rapidly emerging as a fundamental mechanism not only controlling the proper folding of nascent channels but also their subcellular localisation, gating and function. Moreover, studies on various channel subtypes have revealed that glycosylation represents an important determinant by which other signalling pathways modulate channel activity. The discovery of detailed mechanisms of regulation of ion channels by glycosylation provides new insights in the physiology of ion channels and may allow developing new pharmaceutics for the treatment of ion channel-related disorders.


Ion channel N-linked glycosylation O-linked glycosylation Glycan Protein glycosylation 



Acid-sensing ion channel


Neuroblastoma cell


Cath.a-differentiated cell


Voltage-gated calcium channel


Congenital disorders of glycosylation


Cystic fibrosis transmembrane conductance regulator


Chinese hamster ovary cell


Endoplasmic reticulum


ER–Golgi intermediate compartment






Hyperpolarisation-activated cyclic nucleotide-gated channel


Two-pore domain potassium channel


Voltage-gated potassium channel




Long QT syndrome


Murine cortical collecting duct


Voltage-gated sodium channel


Mucin-type O-glycan


Pannexin channel

PNGase F

Peptide-N-glycosidase F


Spodoptera frugiperda cell


Human breast cancer cell


Beta-galactoside alpha-2,3-sialyltransferase 4


Alpha-2,8-sialyltransferase 2


Two-pore channel


Tetratricopeptide repeat-containing Rab8b-interacting protein


Transient receptor potential channel


Transient receptor potential canonical channel


Transient receptor potential melastatin channel


Transient receptor potential polycystin channel


Transient receptor potential vanilloid channel





This work was supported by internal funding from the Institute of Organic Chemistry and Biochemistry (IOCB). JL is supported by a postdoctoral fellowship from IOCB.


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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Organic Chemistry and BiochemistryAcademy of Sciences of the Czech RepublicPragueCzech Republic

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