Lipoxins: update and impact of endogenous pro-resolution lipid mediators
Lipoxins (LXs) are endogenously produced eicosanoids that are typically generated by transcellular biosynthesis. These trihydroxytetraene-containing lipid mediators and their stable synthetic analogues possess a wide spectrum of anti-inflammatory and pro-resolution bioactions both in vitro and in vivo. More recently, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to platelet-derived growth factor (PDGF). Here we review the biosynthesis, metabolism and bioactions of LXs and LX analogues and their therapeutic potential.
KeywordsChronic Obstructive Pulmonary Disease Mesangial Cell ECV304 Cell Tissue Factor Activity Mesangial Cell Proliferation
Work in the authors' laboratory is supported by the Health Research Board, Ireland, Enterprise Ireland, The Welcome Trust, European Commission FP6 funding (LSHM-CT-2004-005033), and The Government of Ireland Programme for Research in Third Level Institutions.
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