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Mammalian Cell Cultures for Biologics Manufacturing

  • Anne KantardjieffEmail author
  • Weichang Zhou
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 139)

Abstract

Biopharmaceuticals represent a growing sector of the pharmaceutical industry, and are used for a wide range of indications, including oncology and rheumatology. Cultured mammalian cells have become the predominant expression system for their production, partly due to their ability to complete the posttranslational modifications required for drug safety and efficacy. Over the past decade, the productivity of mammalian cell culture production processes has growth dramatically through improvements in both volumetric and specific productivities. This article presents an overview of the biologics market, including analysis of sales and approvals; as well as a review of industrial production cell lines and cell culture operations.

Graphical Abstract

Keywords

Biopharmaceuticals Cell culture operations Mammalian cell culture Production cell lines 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Upstream DevelopmentAlexion PharmaceuticalsCheshireUSA
  2. 2.Biologics process DevelopmentWuXi AppTec Co.ShanghaiChina

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