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Engineered Cell–Cell Communication and Its Applications

  • Stephen Payne
  • Lingchong You
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 146)

Abstract

Over the past several decades, biologists have become more appreciative of the fundamental role of intercellular communication in natural systems spanning prokaryotic biofilms to eukaryotic developmental systems and neurological networks. From an engineering perspective, the use of cell–cell communication provides an opportunity to engineer more complex and robust functions using cellular components. Indeed, this strategy has been adopted in synthetic biology in the creation of diverse gene circuits that program spatiotemporal dynamics in one or multiple populations. Gene circuits such as these may offer insights regarding basic biological questions and motifs or serve as a basis for novel applications.

Graphical Abstract

Keywords

Synthetic Biology Quorum Sense Logic Gate Cell Communication Quorum Sense System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Related research in the You lab is supported by NIH (1R01-GM098642), a DuPont Young Professorship (LY), a National Science Foundation CAREER award (LY), a David and Lucile Packard Fellowship (LY), North Carolina Biotechnology Center (2012-MRG-1102), and the Office of Naval Research (N00014-12-1-0631).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringDuke UniversityDurhamUSA
  2. 2.Institute for Genome Sciences and PolicyDuke UniversityDurhamUSA
  3. 3.Center for Systems BiologyDuke UniversityDurhamUSA
  4. 4.CIEMAS 2355DurhamUSA

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