DNAzyme-Functionalized Gold Nanoparticles for Biosensing



Recent progress in using DNAzyme-functionalized gold nanoparticles (AuNPs) for biosensing is summarized in this chapter. A variety of methods, including those for attaching DNA on AuNPs, detecting metal ions and small molecules by DNAzyme-functionalized AuNPs, and intracellular applications of DNAzyme-functionalized AuNPs are discussed. DNAzyme-functionalized AuNPs will increasingly play more important roles in biosensing and many other multidisciplinary applications.

Graphical Abstract

This chapter covers the recent advancement in biosensing applications of DNAzyme-functionalized gold nanoparticles, including the detection of metal ions, small molecules, and intracellular imaging.


Biosensing DNAzyme Gold nanoparticle Intracellular imaging 



Gold Nanoparticle


Deoxyribonucleic Acid


Double-stranded DNA


Poly-(Ethylene Glycol)


Surface Enhanced Raman Spectroscopy


Surface Plasmon Resonance


Single-stranded DNA


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Chemistry and Beckman InstituteUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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