Disposable Bioreactors pp 145-169

Part of the Advances in Biochemical Engineering / Biotechnology book series (ABE, volume 115)

Sensors in Disposable Bioreactors Status and Trends

  • Anne Glindkamp
  • Daniel Riechers
  • Christoph Rehbock
  • Bernd Hitzmann
  • Thomas Scheper
  • Kenneth F. Reardon
Chapter

Abstract

For better control of productivity and product quality, detailed monitoring of various parameters is required. Since disposable bioreactors become more and more important for biotechnological applications, adequate sensors for this type of reactor are necessary. The required properties of sensors used in disposable reactors differ from those of sensors for multiuse reactors. For example, sensors which are in direct contact with the medium must be inexpensive, but do not need a long life-time, since they can be used only once.

This chapter gives an overview on the state of the art and future trends in the field of sensors suited for use in disposable bioreactors. The main focus here is on in situ sensors, which can be based on optical, semiconductor and ultrasonic technologies, but current concepts for disposable sampling units are also reviewed.

Keywords

Disposable reactors Disposable sensors Electrochemical sensors In situ microscopy Optical sensing Ultrasound 

Abbreviations

κ

Adiabatic compressibility

κc

Conductivity

κcell

Cell constant

ρ

Density

ATR

Attenuated total reflectance

CA

Commercially available

CIP

Cleaning in place

cUS

Velocity of ultrasonic wave

IDrain

Drain current

IR

In research

ISFET

Ion-sensitive field-effect transistor

JFET

Junction field-effect transistor

MOSFET

Metal oxide semiconductor field-effect transistor

NA

Not available

NIR

Near infrared

PAT

Process analysis technology

pHFET

pH-sensitive ISFET

R

Resistance

SIP

Sterilization in place

SWIR

Short wave infrared

UDrain

Drain voltage

UGate

Gate voltage

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Anne Glindkamp
    • 1
  • Daniel Riechers
    • 1
  • Christoph Rehbock
    • 1
  • Bernd Hitzmann
    • 1
  • Thomas Scheper
    • 1
  • Kenneth F. Reardon
    • 2
  1. 1.Institute for Technical ChemistryLeibniz University HannoverHannoverGermany
  2. 2.Department of Chemical and Biological EngineeringColorado State UniversityFort CollinsUSA

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