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Complications of GERD: Esophagitis, Stricture, Barrett’s, and Cancer

  • John A. Bonino
  • Prateek Sharma

Keywords

Intestinal Metaplasia Esophageal Adenocarcinoma GERD Symptom Esophageal Stricture Erosive Esophagitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Shaheen N, Provenzale D. The epidemiology of gastroesophagealreflux disease. Am J MedSci2003;326(5):264–273.Google Scholar
  2. 2.
    Castell DO, Tutuian R. Barrett’s esophagus prevalence and epidemiology. Gastrointest Endosc Clin N Am 2003; 13:227–232.PubMedGoogle Scholar
  3. 3.
    Napierkowski J, Wong RK. Extraesophageal manifestations of GERD. Am J Med Sci 2003;326(5):285–293.PubMedGoogle Scholar
  4. 4.
    Vaezi MF. Extraesophageal manifestations of gastroesophageal reflux disease. Clin Cornerstone 2003;5(4): 32–40.Google Scholar
  5. 5.
    Harding SM, Guzzo MR, Richter JE. The Prevalence of gastroesophageal reflux in asthma patients without reflux symptoms.Am J Respir Crit Care Med 2000;162(1): 34–39.PubMedGoogle Scholar
  6. 6.
    Irwin RS, Richter JE. Gastroesophageal reflux and chronic cough. Am J Gastroenterol 2000;95(8):S9–S14.PubMedGoogle Scholar
  7. 7.
    Voutilainen M, Sipponen P, Mecklin JP, et al. Gastroesophageal reflux disease: prevalence, clinical, endoscopic and histopathological findings in 1,128 consecutive patients referred for endoscopy due to dyspeptic and reflux symptoms. Digestion 2000;61: 6–13.PubMedCrossRefGoogle Scholar
  8. 8.
    Johansson KE, Ask P, Boeryd B, et al. Oesophagitis, signs of reflux, and gastric acid secretion in patients with symptoms of gastro-oesophageal reflux disease. Scand J Gastroenerol 1986;21:837–847.Google Scholar
  9. 9.
    Johanson JF. Epidemiology of esophageal and supraesophageal reflux injuries. Am J Med 2000;108(suppl 4a): 99S–103S.PubMedGoogle Scholar
  10. 10.
    Loffeld RJLF, van der Putten ABMM. Rising incidence of reflux oesophagitis in patients undergoing upper gastrointestinal endoscopy. Digestion 2003;68:141–144.PubMedCrossRefGoogle Scholar
  11. 11.
    Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology 2004;126(3):660–664.PubMedCrossRefGoogle Scholar
  12. 12.
    Todd JA, Johnston DA, Dillon JF. The changing spectrum of gastroesophageal reflux disease. Eur J Cancer Prev 2002;11(3):215–219.PubMedCrossRefGoogle Scholar
  13. 13.
    El-Serag HB, Mason AC, Petersen N, Key CR. Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut 2002;50:368–372.PubMedCrossRefGoogle Scholar
  14. 14.
    Rajendra S, Kutty K, Karim N. Ethnic differences in the prevalence of endoscopic esophagitis and Barrett’s esophagus: the long and short of it all. Dig Dis Sci 2004; 49(2):237–242.PubMedCrossRefGoogle Scholar
  15. 15.
    Yeh C, Hsu CT, Ho AS, Sampliner RE, Fass R. Erosive esophagitis and Barrett’s esophagus in Taiwan: a higher frequency than expected. Dig Dis Sci 1997; 42(4):702–706.PubMedCrossRefGoogle Scholar
  16. 16.
    Vaezi MF, Richter MF. Role of acid and duodenogastroesophageal reflux in gastroesophageal reflux disease. Gastroenterology 1996;111:1192–1199.PubMedCrossRefGoogle Scholar
  17. 17.
    Kahrilas PJ. GERD pathogenesis, pathophysiology, and clinical manifestations. Cleve Clin J Med 2003; 70(5):S4–S19.PubMedGoogle Scholar
  18. 18.
    Pace F, Porro GB. Gastroesophageal reflux disease: a typical spectrum of disease (a new conceptual framework is not needed). Am J Gastroenterol 2004;99(5): 946–949.PubMedCrossRefGoogle Scholar
  19. 19.
    El-Serag HB, Sonnenberg A. Outcome of erosive reflux esophagitis after Nissen fundoplication. Am J Gastroenterol 1999;94(7):1771–1776.PubMedCrossRefGoogle Scholar
  20. 20.
    Fass R, Ofman JJ. Gastroesophageal reflux disease: should we adopt a new conceptual framework? 2002;97(8):1901–1909.Google Scholar
  21. 21.
    Collen MJ, Abdulian JD, Chen YK. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol 1995; 90(7):1053–1057.PubMedGoogle Scholar
  22. 22.
    Fennerty MB. The continuum of GERD complications. Cleve Clin J Med 2003;70(5):S33–S50.PubMedCrossRefGoogle Scholar
  23. 23.
    Kuo W, Kalloo A. Reflux strictures of the esophagus. Gastrointest Endosc Clin N Am 1998;8:273–281.PubMedGoogle Scholar
  24. 24.
    Sonnenberg A, Avidan B, Schnell TG, Sontag SJ. Acid reflux is a poor predictor for severity of erosive reflux esophagitis. Dig Dis Sci 2002;47(11):2565–2573.PubMedGoogle Scholar
  25. 25.
    Venables TL, Newland RD, Patel AC, Hole J, Wilcock C, Turbitt ML. Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 mg twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice. Scand J Gastroenterol 1997;32(10): 965–973.Google Scholar
  26. 26.
    Chiba N, De Gara CJ, Wilkinson JM, Hunt RH. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis.Gast roenterology 1997;112(6):1798–1810.Google Scholar
  27. 27.
    Holtmann G, Cain C, Malfertheiner P. Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazole. Gastroenterology 1999; 117(1):11–16.PubMedCrossRefGoogle Scholar
  28. 28.
    Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999;45:172–180.PubMedCrossRefGoogle Scholar
  29. 29.
    Lundell L, Miettinen P, Myrvold HE, et al. Long-term management of gastro-oesophageal reflux disease with omeprazole or open anti-reflux surgery: results of a prospective, randomized clinical trial. The Nordic GORD Study Group. Eur J Gastroenterol Hepatol 2000; 12(8):879–887.PubMedCrossRefGoogle Scholar
  30. 30.
    Richter JE. Peptic strictures of the esophagus. Gastroenterol Clin N Am 1999;28:875–891.Google Scholar
  31. 31.
    Marks RD, Shukla M. Diagnosis and management of peptic esophageal strictures. Gastroenterologist 1996;4: 223–237.PubMedGoogle Scholar
  32. 32.
    El-Serag HB, Sonnenber A. Associations between diff erent forms of gastro-oesophageal reflux disease. Gut 1997; 41:594–599.PubMedCrossRefGoogle Scholar
  33. 33.
    Johanson JF. Epidemiology of esophageal and supraesophageal reflux injuries. Am J Med 2000;108(suppl 4a): 99S–103S.PubMedGoogle Scholar
  34. 34.
    Locke RG. Can symptoms predict endoscopic findings in GERD? Gastrointest Endosc 2003;58(5):661–670.PubMedCrossRefGoogle Scholar
  35. 35.
    Berstad A, Weberg R, Froyshov Larsen I, et al. Relationship of hiatus hernia to reflux oesophagitis. A prospective study of coincidence, using endoscopy. Scand J Gastroenterol 1986;21(1):55–58.PubMedGoogle Scholar
  36. 36.
    Mazzadi SA, Garcia AO, Salis GB, Chiocca JC. Peptic esophageal stricture: a report from Argentina. Dis Esophagus 2004;17(1):63–66.PubMedCrossRefGoogle Scholar
  37. 37.
    Spechler SJ. AGA technical review on treatment of patients with dysphagia caused by benign disorders of the distal esophagus. Gastroenterology 1999;117: 233–254.PubMedGoogle Scholar
  38. 38.
    Smith PM, Kerr GD, Cockel R, et al. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture. Gastroenterology 1994;107:1312–1318.PubMedGoogle Scholar
  39. 39.
    Nelson DB, Sanderson SJ, Azar MM. Bacteremia with esophageal dilation. Gastrointest Endosc 1998;48:563–567.PubMedCrossRefGoogle Scholar
  40. 40.
    Botoman VA, Surawicz CM. Bacteremia with gastrointestinal endoscopic procedures. Gastrointest Endosc 1986;33:342–346.Google Scholar
  41. 41.
    Sharma P, McQuaid K, Dent J, Fennerty MB, et al.A critical review of the diagnosis and management of Barrett’s esophagus: the AGA Chicago Workshop. Gastroenterology 2004;127(1):310–330.PubMedCrossRefGoogle Scholar
  42. 42.
    Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS. Is there publication bias in the reporting of cancer risk in Barrett’s esophagus? Gastroenterology 2000;119: 333–338.Google Scholar
  43. 43.
    Shaheen N, Ransohoff DF. Gastroesophageal reflux, Barrett esophagus, and esophageal cancer. Scientific review. JAMA 2002;287(15):1972–1979.PubMedGoogle Scholar
  44. 44.
    Koop H. Gastroesophageal reflux disease and Barrett’s esophagus. Endoscopy 2004;36:103–109.PubMedCrossRefGoogle Scholar
  45. 45.
    Conio M, Cameron AJ, Romero Y, et at. Secular trends in the epidemiology and outcome of Barrett’s oesophagus in Olmsted County, Minnesota. Gut 2001;48:308–309.CrossRefGoogle Scholar
  46. 46.
    Rex DK, Cummings OW, Shaw M, et al. Screening for Barrett’s esophagus in colonoscopy patients with and without heartburn. Gastroenterology 2003;125: 1670–1677.PubMedGoogle Scholar
  47. 47.
    Sharma P, Sidorenko EI. Are screening and surveillance for Barrett’s oesophagus really worthwhile? Gut 2005; 54(suppl 1):i27–i32.PubMedGoogle Scholar
  48. 48.
    Fitzgerald RC, Farthing MJG. The pathogenesis of Barrett’s esophagus. Gastrointest Endosc Clin N Am 2003;13(2):233–255.PubMedCrossRefGoogle Scholar
  49. 49.
    Neumann CS, Cooper BT. 24 Hour ambulatory oesophageal pH monitoring in uncomplicated Barrett’s oesophagus. Gut 1994;35:1352–1355.PubMedGoogle Scholar
  50. 50.
    Champion G, Richter JE, Vaezi MF. Duodenogastroesophageal reflux: relationship to pH and importance in Barrett’s esophagus. Gastroenterology 1994;1076(3): 747–754.Google Scholar
  51. 51.
    Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999;340: 825–831.PubMedCrossRefGoogle Scholar
  52. 52.
    Gerson LB, Edson R, Lavori PW, Triadafilopoulos G. Use of a simple symptom questionnaire to predict Barrett’s esophagus in patients with symptoms of gastroesophageal reflux. Am J Gastroenterol 2001;96: 2005–2011.PubMedGoogle Scholar
  53. 53.
    Connor MJ, Sharma P. Chromoendoscopy and magni.cation endoscopy in Barrett’s esophagus. Gastrointest Endosc Clin N Am 2003;13(2):269–277.PubMedCrossRefGoogle Scholar
  54. 54.
    Richter JE. Duodenogastric reflux-induced esophagitis. Curr Treat Options Gastroenterol 2004;7:53–58.PubMedGoogle Scholar
  55. 55.
    Wong Kee Song LM, Marcon NE. Fluorescence and Raman spectroscopy. Gastrointest Endosc Clin N Am 2003;13(2):279–296.PubMedGoogle Scholar
  56. 56.
    Poneros JM, Nishioka NS. Diagnosis of Barrett’s esophagus using optical coherence tomography. Gastrointest Endosc Clin N Am 2003;13(2):309–323.PubMedCrossRefGoogle Scholar
  57. 57.
    Streitz JM Jr, Andrews CW Jr, Ellis FH Jr. Endoscopic surveillance of Barrett’s esophagus. Does it help? J Thorac Cardiovasc Surg 1993;105:383–388.PubMedGoogle Scholar
  58. 58.
    Peters JH, Clark GWB, Ireland AP, et al. Outcome of adenocarcinoma arising in Barrett’s esophagus in endoscopically surveyed and nonsurveyed patients. J Gen Thorac Surg 1994;108:813–821.Google Scholar
  59. 59.
    Reid BJ, Blount PL, Rabinovitch PS. Biomarkers in Barrett’s esophagus. Gastrointest Endosc Clin N Am 2003;13:369–397.PubMedCrossRefGoogle Scholar
  60. 60.
    Ouatu-Lascar R, Triadafilopoulos G. Complete elimination of reflux symptoms does not guarantee normalization of intraesophageal acid reflux in patient’s with Barrett’s esophagus. Am J Gastroenterol 1998; 93(5):711–716.PubMedCrossRefGoogle Scholar
  61. 61.
    Souza RF, Shewmake K, Terada LS, Spechler SJ. Acid exposure activates the mitogen-activated protein kinase pathways in Barrett’s esophagus. Gast roenterology 2002;122:299–307.Google Scholar
  62. 62.
    Corey KE, Schmitz SM, Shaheen NJ. Does a surgical anti-reflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett’s esophagus: a meta-analysis. Am J Gastroenterol 2003;98(11): 2310–2314.CrossRefGoogle Scholar
  63. 63.
    Photodynamic therapy for dysplastic Barrett’s oesophagus: a prospective, double blind, randomised, placebo controlled trial. Gut 2000;47:612–617.Google Scholar
  64. 64.
    Booger JV, Hillegersberg RV, Siersema PD, de Bruin RWF, Tilanus HW. Endoscopic ablation therapy for Barrett’s esophagus with high-grade dysplasia: a review. Am J Gastroenterol 1999;94:1153–1158.Google Scholar
  65. 65.
    Sampliner RE and The Practice Parameters Committee of the American College of Gastroenterology. Updated guidelines on the diagnosis, surveillance, and therapy of Barrett’s esophagus. Am J Gastroenterol 2002;97: 1888–1895.PubMedGoogle Scholar
  66. 66.
    Shaheen NJ, Wei JT. Epidemiology of esophageal adenocarcinoma. In press.Google Scholar
  67. 67.
    Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287–1289.PubMedCrossRefGoogle Scholar
  68. 68.
    Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS. Is there publication bias in the reporting of cancer risk in Barrett’s esophagus? Gastroenterology 2000; 119(2):333–338.PubMedCrossRefGoogle Scholar
  69. 69.
    Fitzgerald RC, Farthing MJ. The pathogenesis of Barrett’s esophagus. Gast rointest Endosc Clin N Am 2003;13:233–255.Google Scholar
  70. 70.
    Reid BJ, Blount PL, Rabinovitch PS. Biomarkers in Barrett’s esophagus. Gast rointest Endosc Clin N Am 2003;13:369–397.Google Scholar
  71. 71.
    Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999; 340(11):825–831.PubMedCrossRefGoogle Scholar
  72. 72.
    Lagergren J, Bergstrom R, Nyren O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med 1999;130(11):883–890.PubMedGoogle Scholar
  73. 73.
    Enzinger PC, Mayer RJ. Esophageal cancer. N Engl J Med 2003;349(23):2241–2252.PubMedCrossRefGoogle Scholar
  74. 74.
    Pech O, May A, Gossner L, et al. Barrett’s esophagus: endoscopic resection. Gast rointest Endosc Clin N Am 2003;13(3):505–512.Google Scholar

Copyright information

© Springer-Verlag London Limited 2006

Authors and Affiliations

  • John A. Bonino
  • Prateek Sharma

There are no affiliations available

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