Animal and In Vitro Models for Studying Hypoxic Pulmonary Vasoconstriction

  • Jane A. Madden
  • John B. Gordon
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 252)

Summary

Is there or will there ever be a best model in which to study HPV? Probably, not. The use of reductionist approaches to identify mechanisms underlying pulmonary vasomotor tone has been something of a double-edged sword. Studies of isolated vessels or cultured cells have elucidated cellular mechanisms controlling synthesis or inhibition of potentially important modulators and mediators. On the other hand, many of these appear to play little role in vivo. Discordant responses to hypoxia between more and less reductionist preparations suggest that deconstructing the lung may interrupt signaling, metabolic, and mechanical pathways critical to integrated in vivo hypoxic responses. Development of reductionist preparations that retain mechanisms underlying in vivo responses is imperative for complete understanding of HPV and the ultimate application of findings to the clinical situation. Ultimately, however, whatever model is studied, the knowledge derived from it will further our understanding of HPV, and also fundamental mechanisms inherent to the entire vasculature.

Keywords

Nitric Oxide Pulmonary Artery Pulmonary Vasculature Hypoxic Response Hypoxic Pulmonary Vasoconstriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Jane A. Madden
    • 1
  • John B. Gordon
    • 1
  1. 1.Medical College of WisconsinMilwaukeeUSA

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