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Nuclear Factor-κB Activation Mediates Cellular Transformation, Proliferation, Invasion Angiogenesis and Metastasis of Cancer

  • Shishir Shishodia
  • Bharat B. Aggarwal
Part of the Cancer Treatment and Research book series (CTAR, volume 119)

Conclusions

Overall these studies clearly demonstrate that NF-κB plays a critical role in tumorigenesis. Similarity, suppression of NF-κB has the ability to inhibit various steps in the tumorigenic process. Design of inhibitors that are pharmacologically safe will be critical for the treatment of cancer. Because of the multiple agents that activate NF-κB through diverse pathways, it is unlikely that any single inhibitor of NF-κB would be effective against all tumors.

Keywords

Ursolic Acid Betulinic Acid Ataxia Telangiectasia Apical Ectodermal Ridge Cigarette Smoke Condensate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Shishir Shishodia
    • 1
  • Bharat B. Aggarwal
    • 1
  1. 1.Department of BioimmunotherapyThe University of Texas M. D. Anderson Cancer CenterHouston

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