Role of COX-2 in Inflammatory and Degenerative Brain Diseases

  • Luisa Minghetti
Part of the Subcellular Biochemistry book series (SCBI, volume 42)

In the last decade, the potential role of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) in brain diseases has been extensively studied. COX-2 over-expression has been associated with neurotoxiticy in acute conditions, such as hypoxia/ischemia and seizures, as well as in inflammatory chronic diseases, including Creutzfeldt-Jakob disease (CJD) and Alzheimer’s disease (AD). However, the role played by COX-2 in neurodegenerative diseases is still controversial and further clinical and experimental studies are warranted. In addition, the emerging role of COX-2 in behavioural and cognitive functions strongly indicates that studies aimed at improving our knowledge of the physiological role of COX-2 in the central nervous system are crucial to fully understand the pros and cons of its manipulation in disabling neurological diseases


Microglial Cell Prion Disease Bovine Spongiform Encephalopathy Kynurenic Acid Transmissible Spongiform Encephalopathy 
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© Springer 2007

Authors and Affiliations

  • Luisa Minghetti
    • 1
  1. 1.Department of Cell Biology and NeurosciencesIstituto Superiore di SanitáRomeItaly

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