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Dimerization and Oligomerization of Rhodopsin and Other G Protein-Coupled Receptors

  • Sławomir Filipek
  • Anna Modzelewska
  • Krystiana A. KrzyŚko
Part of the Challenges and Advances in Computational Chemistry and Physics book series (COCH, volume 4)

Abstract

Dimerization, and more generally oligomerization, of G protein-coupled receptors (GPCRs) is experimentally proven and possibly all GPCRs act in oligomeric form. The coupling with G protein, phosphorylation by kinase and binding to arrestin what starts internalization process have also been shown to be influenced by the oligomeric state of the receptors. Cooperative interactions within homo- and heterodimers of GPCRs may be critical for the propagation of an external signal across the cell membrane, activation of a G protein and passing the signal down to effector proteins

Keywords

Rhodopsin GPCR membrane proteins dimerization oligomerization G protein arrestin signal transduction 

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Copyright information

© Springer 2007

Authors and Affiliations

  • Sławomir Filipek
    • 1
  • Anna Modzelewska
    • 1
  • Krystiana A. KrzyŚko
    • 1
  1. 1.International Institute of Molecular and Cell BiologyWarsawPoland

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