Refinement of Nucleic Acid Structures with Residual Dipolar Coupling Restraints in Cartesian Coordinate Space
During the past decade, measurement of residual dipolar constants (RDC) in weakly oriented molecules has been established as an invaluable source of structural information, and RDC data are now often used in structure determination of biological macromolecules via NMR [1–4]. Indeed, incorporation of RDC data in nucleic acid structure refinement apparently improves the accuracy and precision of global conformations and possibly local conformations as well [5–7].
KeywordsRoot Mean Square Internal Ribosome Entry Site Nuclear Overhauser Effect Distance Restraint Alignment Tensor
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