Virus Evolution in the Face of the Host Response

  • Esteban Domingo
Conference paper


Microbial infections are highly dynamic. Viruses have evolved two main strategies against the host response: interaction or evasion. Interaction is typical of complex DNA viruses. Their genomes encode a number of proteins that exert modulatory functions that alter the immune response of the host. Evasion strategy is used mainly by RNA viruses, and is based on high mutation rates and quasispecies dynamics. The complexity of viral populations demands research on new antiviral strategies that take into consideration the adaptive potential of viruses, in particular RNA viruses.


High Mutation Rate Virus Evolution Evasion Strategy Antiviral Strategy Major Histocompatibility Complex Protein 
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Copyright information

© IAEA 2005

Authors and Affiliations

  • Esteban Domingo
    • 1
    • 2
  1. 1.Centro de Investigación en Sanidad Animal (CISA-INIA)Valdeolmos, MadridSpain
  2. 2.Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM)Universidad Autónoma de MadridMadridSpain

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