Modulation of MHC Class II Signal Transduction by CD19

  • David M. Mills
  • John C. Stolpa
  • John C. Cambier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 596)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Siemasko, K., and M. R. Clark. 2001. The control and facilitation of MHC class II antigen processing by the BCR. Curr Opin Immunol 13:32.Google Scholar
  2. 2.
    Cyster, J. G. 1999. Chemokines and cell migration in secondary lymphoid organs. Science 286:2098.Google Scholar
  3. 3.
    Okada, T., and J. G. Cyster. 2006. B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol.Google Scholar
  4. 4.
    Dal Porto, J. M., S. B. Gauld, K. T. Merrell, D. Mills, A. E. Pugh-Bernard, and J. Cambier. 2004. B cell antigen receptor signaling 101. Mol Immunol 41:599.Google Scholar
  5. 5.
    Anzelon, A. N., H. Wu, and R. C. Rickert. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4:287.Google Scholar
  6. 6.
    Wang, Y., S. R. Brooks, X. Li, A. N. Anzelon, R. C. Rickert, and R. H. Carter. 2002. The physiologic role of CD19 cytoplasmic tyrosines. Immunity 17:501.Google Scholar
  7. 7.
    Fujimoto, M., J. C. Poe, P. J. Jansen, S. Sato, and T. F. Tedder. 1999. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. J Immunol 162:7088.Google Scholar
  8. 8.
    Gardby, E., X. J. Chen, and N. Y. Lycke. 2001. Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching. Scand J Immunol 53:13.Google Scholar
  9. 9.
    Yazawa, N., M. Fujimoto, S. Sato, K. Miyake, N. Asano, Y. Nagai, O. Takeuchi, K. Takeda, H. Okochi, S. Akira, T. F. Tedder, and K. Tamaki. 2003. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102:1374.Google Scholar
  10. 10.
    Engel, P., L. J. Zhou, D. C. Ord, S. Sato, B. Koller, and T. F. Tedder. 1995. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39.Google Scholar
  11. 11.
    Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352.Google Scholar
  12. 12.
    Andre, P., J. C. Cambier, T. K. Wade, T. Raetz, and W. F. Wade. 1994. Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules. J Exp Med 179:763.Google Scholar
  13. 13.
    Cambier, J. C., and K. R. Lehmann. 1989. Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med 170:877.Google Scholar
  14. 14.
    Lang, P., J. C. Stolpa, B. A. Freiberg, F. Crawford, J. Kappler, A. Kupfer, and J. C. Cambier. 2001. TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science 291:1537.Google Scholar
  15. 15.
    Bobbitt, K. R., and L. B. Justement. 2000. Regulation of MHC class II signal transduction by the B cell coreceptors CD19 and CD22. J Immunol 165:5588.Google Scholar
  16. 16.
    Mills, D. M., J. C. Stolpa, and J. C. Cambier. 2004. Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22. J Immunol 172:195.Google Scholar
  17. 17.
    Monks, C. R., B. A. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82.Google Scholar
  18. 18.
    Otero, D. C., S. A. Omori, and R. C. Rickert. 2001. Cd19-dependent activation of Akt kinase in B-lymphocytes. J Biol Chem 276:1474.Google Scholar
  19. 19.
    Buhl, A. M., and J. C. Cambier. 1999. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton’s tyrosine kinase. J Immunol 162:4438.Google Scholar
  20. 20.
    Sato, S., N. Ono, D. A. Steeber, D. S. Pisetsky, and T. F. Tedder. 1996. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J Immunol 157:4371.Google Scholar
  21. 21.
    Stohl, W., D. Xu, K. S. Kim, T. F. Tedder, and S. Sato. 2005. Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. Clin Immunol 116:257.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • David M. Mills
    • 1
  • John C. Stolpa
    • 2
  • John C. Cambier
    • 3
  1. 1.The Burnham InstituteLa Jolla
  2. 2.Finnegan, Henderson, Farabow, Garrett & Dunner, LLPWashington
  3. 3.Integrated Department of Immunology, National Jewish Medical and Research CenterUniversity of Colorado Health Sciences CenterDenver

Personalised recommendations