Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Disease

  • Thomas T. MacDonald
  • Giovanni Monteleone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 579)


Crohn’s disease (CD) and ulcerative colitis (UC) are caused by the over-activity of the immune system. Current and novel therapies are designed to dampen these over-active responses. Analysis of the types of immune responses ongoing in diseased mucosa of inflammatory bowel disease patients has revealed that CD and UC are fundamentally different diseases. The former has the molecular imprints of a Th1 dominant cell-mediated hypersensitivity response whereas the latter appears to involve antibody-mediated hypersensitivity.


Crohns Disease Inflammatory Bowel Disease Ulcerative Colitis Lamina Propria Crohns Disease Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© and Springer Science+Business Media 2006

Authors and Affiliations

  • Thomas T. MacDonald
    • 1
  • Giovanni Monteleone
    • 2
  1. 1.University of Southampton School of MedicineSouthhamptonUK
  2. 2.Department of GastroenterologyUniversity Tor VergataRomeItaly

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